State of the Art in Industrial Application of Amino-1,2,4-Triazoles

The review summarizes information regarding the industrial use of 3- and 4-amino-1,2,4- triazoles, the basic raw material for the industry of fine organic synthesis. A description of the existing production methods for the synthesis of 3- and 4-amino-1,2,4-triazoles under laboratory conditions is provided. Three main areas of use of these amines and their derivatives have been identified: Agriculture, medicine, high-energy substances and gas-generating composition. It has been shown that one of the earliest areas of widespread use of 3- and 4-amino-1,2,4-triazoles is the production of plant protection products. The mass production of various insecticides, fungicides, plant growth regulators, retardants, and nitrification inhibitors of nitrogen fertilizers has been organized. The use of these amines in medicine consists of the production of known drugs, such as furazonal, thiotriazoline and cardiotril, which have hepatoprotective, antioxidant, and anti-ischemic activity. The industrial processing of 3- and 4-amino-1,2,4-triazoles into explosives, solid propellants and gas-generating compositions is a third well-known field of application. The high reactivity of amines and the variety of areas for their use are explained. A significant emphasis is given to the analysis of aminotriazoles. This is the production of new types of salts and electrically conductive ionic liquids, corrosion inhibitors of non-ferrous metals, and catalysts for curing epoxy resins. The results of recent studies are discussed, and the prospects for using 3- and 4-amino-1,2,4-triazoles as raw materials for the production of new reagents in analytical chemistry, proton-exchange membranes, and new condensed nitrogen-containing heterocycles are explained.