The Chemistry and Biology of Rhazinilam and Analogues

Olivier Baudoin; Daniel Guenard; Francoise Gueritte

doi:10.2174/1570193043403226

ISSN: 1570-193X
E-ISSN: 1875-6298

The Chemistry and Biology of Rhazinilam and Analogues
Authors: Olivier Baudoin¹, Daniel Guenard² and Francoise Gueritte³
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¹ Institut de Chimie des Substances Naturelles, CNRS, Avenue de la Terrasse, 91198 Gif-sur- Yvette Cedex, France ² Institut de Chimie des Substances Naturelles, CNRS, Avenue de la Terrasse, 91198 Gif-sur- Yvette Cedex, France ³ Institut de Chimie des Substances Naturelles, CNRS, Avenue de la Terrasse, 91198 Gif-sur- Yvette Cedex, France
Source: Mini-Reviews in Organic Chemistry, Volume 1, Issue 3, Jul 2004, p. 333 - 341
DOI: https://doi.org/10.2174/1570193043403226
- Available online: 01 Jul 2004

Abstract

Rhazinilam (1) is a natural substance with unique tubulin-binding properties. The present review describes the isolation and structure elucidation of (1), the available data regarding its biological properties, its semi- and total syntheses and its structure-activity relationships through the synthesis of analogues.

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Article Type: Review Article

Keyword(s): analogues; rhazinilam; semisynthesis; structure-activity relationships; total synthesis; tubulin

The Chemistry and Biology of Rhazinilam and Analogues

Abstract

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