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- Volume 22, Issue 15, 2022
Mini Reviews in Medicinal Chemistry - Volume 22, Issue 15, 2022
Volume 22, Issue 15, 2022
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Medicinal Plants in Cancer Treatment: Contribution of Nuclear Factor- Kappa B (NF-kB) Inhibitors
Authors: Rina Das, Dinesh K. Mehta and Meenakshi DhanawatNuclear factor-kappa B (NF-ΚB) is one of the principal inducible proteins and a predominant transcription factor that is known to control gene expression in mammals. It plays a pivotal role in regulating cell signalling in the body under certain physiological and pathological conditions. In cancer cells, such as colon, breast, pancreatic, ovarian, melanoma, and lymphoma, the NF-ΚB pathway is active. In cellular proliferation Read More
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An Update on Arginase Inhibitors and Inhibitory Assays
Authors: Jason Muller, Rym Attia, Andy Zedet, Corine Girard and Marc PudloArginase, which converts arginine into ornithine and urea, is a promising therapeutic target. Arginase is involved in cardiovascular diseases, parasitic infections and through a critical role in immunity, in some cancers. There is a need to develop effective arginase inhibitors and therefore efforts to identify and optimize new inhibitors are increasing. Several methods of evaluating arginase activity are available, but few direc Read More
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The Role of Epigenetic Mechanisms in Autoimmune, Neurodegenerative, Cardiovascular, and Imprinting Disorders
Authors: Ram Sharma, Sachin Sharma, Amandeep Thakur, Arshdeep Singh, Jagjeet Singh, Kunal Nepali and Jing P. LiouEpigenetic mutations like aberrant DNA methylation, histone modifications, or RNA silencing are found in a number of human diseases. This review article discusses the epigenetic mechanisms involved in neurodegenerative disorders, cardiovascular disorders, auto-immune disorders and genomic imprinting disorders. In addition, emerging epigenetic therapeutic strategies for the treatment of such disorders are presented Read More
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Cathepsin B-A Neuronal Death Mediator in Alzheimer’s Disease Leading to Neurodegeneration
The lysosomal cysteine protease enzyme, named Cathepsin B, mainly degrades the protein and manages its average turnover in our body. The Cathepsin B active form is mostly present inside the lysosomal part at a cellular level, providing the slightly acidic medium for its activation. Multiple findings on Cathepsin B reveal its involvement in neurons’ degeneration and a possible role as a neuronal death mediator in several neu Read More
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A Review on Structure-Activity Relationships of Glycyrrhetinic Acid Derivatives with Diverse Bioactivities
Authors: Yuebin Liu, Ruilong Sheng, Junting Fan and Ruihua GuoPentacyclic triterpenoids, consisting of six isoprene units, are a kind of natural active substance. At present, numerous pentacyclic triterpenes have been identified and classified into four subgroups of oleanane, ursane, lupane, and xylene on the basis of the carbon skeleton. Among them, oleanane is the most popular due to its rich backbone and diverse bioactivities. 18β-Glycyrrhetinic acid (GA), an oleanane-type pentacycl Read More
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Volumes & issues
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Volume 25 (2025)
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Volume 24 (2024)
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Volume 23 (2023)
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Volume 22 (2022)
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Volume 21 (2021)
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Volume 20 (2020)
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Volume 19 (2019)
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Volume 18 (2018)
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Volume 17 (2017)
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Volume 16 (2016)
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Volume 15 (2015)
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Volume 14 (2014)
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Volume 13 (2013)
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Volume 12 (2012)
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Volume 11 (2011)
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Volume 10 (2010)
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Volume 9 (2009)
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Volume 8 (2008)
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Volume 7 (2007)
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Volume 6 (2006)
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Volume 5 (2005)
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Volume 4 (2004)
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Volume 3 (2003)
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Volume 2 (2002)
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Volume 1 (2001)
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