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- Volume 2, Issue 1, 2002
Mini Reviews in Medicinal Chemistry - Volume 2, Issue 1, 2002
Volume 2, Issue 1, 2002
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Alzheimer's Disease: Targets For Drug Development
By A.J. LarnerThe numerous advances in the understanding of the neurobiology of Alzheimer's disease in the past 15 years have suggested many new potential targets for therapeutic intervention. This article gives a broad overview of the spectrum of targets for AD treatment, with particular emphasis on amyloid β-peptides and tau protein.
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Cholinergic Drugs in Pharmacotherapy of Alzheimer's Disease
Authors: P. Camps and D. Munoz-TorreroThe cholinergic hypothesis of Alzheimer's disease has spurred the development of numerous structural classes of compounds with different pharmacological profiles aimed at increasing central cholinergic neurotransmission, thus providing a symptomatic treatment for this disease. Indeed, the only drugs currently approved for the treatment of Alzheimer's disease are cholinomimetics with the pharmacological profil Read More
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Rational Design of Reversible Acetylcholinesterase Inhibitors
Authors: X. Barril, S.G. Kalko, M. Orozco and F. LuqueA large amount of structural information on AChE and AChE-inhibitor complexes is currently available. Based on that, molecular modeling studies can be intensively used to gain insight into the mechanism of action of the enzyme and the molecular determinants that modulate the potency of inhibitors. In turn, this knowledge can be exploited to design new compounds leading to more effective cholinergic strategies. This manu Read More
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Non-Cholinergic Pharmacotherapy Approaches to the Future Treatment of Alzheimer's Disease
Authors: A. Castro, S. Conde, M. Rodriguez-Franco and A. MartinezResearch on the molecular basis of Alzheimer's disease has elucidated pathogenic pathways from which a range of rational pharmacological interventions has emerged. The most promising strategies involve approaches to retarding, halting or preventing the formation or accumulation of beta amyloid plaques and neurofibrillary tangles. Other therapeutic approaches include those acting via excitatory amino acid receptors Read More
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Transgenic Mouse Models with Tau Pathology to Test Therapeutic Agents for Alzheimer's Disease
Authors: F. Hernandez, F. Lim, J.J. Lucas, C. Perez-Martin, F. Moreno and J. AvilaThe deposit of two proteins in the brain characterizes Alzheimer's disease: deposits of β-amyloid protein to form senile plaques and tau protein in neurofibrillary tangles. This review discusses transgenic animals overexpressing normal or mutated tau protein as well as kinases involved in tau hyperphosphorylation. These animals hold a great potential as tools to test the effects of forthcoming therapeutical agents for Alzheimer's disease.
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Pharmacogenomics in Alzheimer's Disease
By R. CacabelosAlzheimer's disease (AD) is a complex disorder associated with multiple genetic defects either mutational or of susceptibility. Information available on AD genetics does not explain in full the etiopathogenesis of AD, suggesting that environmental factors and / or epigenetic phenomena may also contribute to AD pathology and phenotypic expression of dementia. The genomics of AD is still in its infancy, but is helping to understand Read More
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Towards Alzheimer's Disease Vaccination
By B. SolomonActive and passive immunization against fibrillar β-amyloid of various mice models of Alzheimer's disease leads to the disaggregation and inhibition of plaque formation. Preliminary results showing improved behaviour and memory function obtained after administration of anti-β-amyloid vaccines to transgenic mice encourage these and related approaches for testing in the treatment and prevention of Alzheimer's disease.
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Volumes & issues
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Volume 25 (2025)
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Volume 24 (2024)
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Volume 23 (2023)
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Volume 22 (2022)
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Volume 21 (2021)
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Volume 20 (2020)
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Volume 19 (2019)
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Volume 18 (2018)
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Volume 17 (2017)
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Volume 16 (2016)
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Volume 15 (2015)
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Volume 14 (2014)
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Volume 13 (2013)
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Volume 12 (2012)
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Volume 11 (2011)
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Volume 10 (2010)
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Volume 9 (2009)
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Volume 8 (2008)
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Volume 7 (2007)
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Volume 6 (2006)
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Volume 5 (2005)
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Volume 4 (2004)
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Volume 3 (2003)
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Volume 2 (2002)
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Volume 1 (2001)
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