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- Volume 12, Issue 3, 2012
Mini Reviews in Medicinal Chemistry - Volume 12, Issue 3, 2012
Volume 12, Issue 3, 2012
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oa Editorial [Hot Topic: Looking Beyond the Obvious: Search for Novel Targets and Drugs for Reducing the Burden of Infectious Diseases (Guest Editor: Neelima Arora)]
Authors: Neelima Arora and Amit Kumar BanerjeeLife is not easy, it never was. With every breath, we are exposed to hundreds of infections, every passing second, a new fear of catching one infection or the other inflicts our mind. Infectious diseases claim more lives every year than all the casualties of wars since historic times. Infectious agents who live in, on and around us have emerged as biggest scourge of mankind causing significant morbidity and mortality. Every ye Read More
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Targeting Tuberculosis: A Glimpse of Promising Drug Targets
Authors: N. Arora and A. K. BanerjeeTuberculosis caused by Mycobacterium tuberculosis has emerged as the biggest curse of our time causing significant morbidity and mortality. Increasing resistance in mycobacterium to existing drugs calls for exploration of metabolic pathways for finding novel drug targets and also for prioritization of known drug targets. Recent advances in molecular biology, bioinformatics and structural biology coupled with availability Read More
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Daptomycin: A Review of Properties, Clinical Use, Drug Delivery and Resistance
Authors: C. Vilhena and A. BettencourtDaptomycin is a branched cyclic anionic lipopeptide antibiotic that was discovered in the early 1980's but got the FDA approval only in 2003. This novel pharmaceutical molecule has demonstrated great in vitro activity against a wide range of aerobic and anaerobic gram-positive bacteria, including methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci. Daptomycin has a unique mechanism of act Read More
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New Targets, New Hope: Novel Drug Targets for Curbing Malaria
Authors: N. Arora and A. K. BanerjeeMalaria continues to plague the tropical and subtropical regions causing high morbidity and mortality. Every year, millions die due to lack of affordable and effective anti-malarial drugs. Malaria poses significant threat to half of the world's population and our arsenal to combat this disease is nearly empty. Pharmaceutical companies shy away from investing in research and development for anti-malarial drugs and have shun Read More
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Ru(II)-Based Antimicrobials: Looking Beyond Organic Drugs
Authors: A. I. Ramos, T. M. Braga and S. S. BragaThis review deals with the bactericidal, anti-fungal and even anti-parasitary properties of ruthenium complexes, both inorganic and organometallic, establishing comparisons between these and the available commercial drugs. The description is mostly composed of results found in the literature of the past two decades, complemented with relevant results from our group's research on antimicrobial ruthenium complexes. The co Read More
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Targeting Strategies for Human Immunodeficiency Virus: A Combinatorial Approach
Authors: S. K. Saxena, A. Gupta, K. Bhagyashree, R. Saxena, N. Arora, A. K. Banerjee, A. K. Tripathi, M. J.N. Chandrasekar, N. Gandhi and M. P.N. NairThe battle between human and the Human immunodeficiency virus (HIV) is on, with both of them rapidly improving their attacking and defense strategies. Many therapeutic agents for HIV infection have been designed and developed, However there are various aspects, like novel targets against HIV, which are yet to be unfolded with a goal of designing and developing novel drug molecules against HIV. This article reviews Read More
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Keto and Exomethylene Pyranonucleosides as Antitumor Agents
Authors: E. Tsoukala, S. Manta, C. Kiritsis and D. KomiotisNucleosides and their analogues take an important place in medicinal chemistry as the structural basis for the development of therapeutic agents. Recently, there has been a renewed interest in the synthesis of keto and exomethylene pyranonucleosides, due to their high cytotoxicity in vitro and powerful inhibitory action in vivo. Their mode of action probably involves their ability to act as acceptors in a Michael-addition mechanis Read More
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Volumes & issues
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Volume 25 (2025)
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Volume 24 (2024)
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Volume 23 (2023)
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Volume 22 (2022)
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Volume 21 (2021)
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Volume 20 (2020)
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Volume 19 (2019)
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Volume 18 (2018)
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Volume 17 (2017)
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Volume 16 (2016)
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Volume 15 (2015)
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Volume 14 (2014)
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Volume 13 (2013)
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Volume 12 (2012)
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Volume 11 (2011)
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Volume 10 (2010)
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Volume 9 (2009)
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Volume 8 (2008)
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Volume 7 (2007)
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Volume 6 (2006)
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Volume 5 (2005)
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Volume 4 (2004)
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Volume 3 (2003)
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Volume 2 (2002)
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Volume 1 (2001)
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