Toward Early Diagnosis of Colorectal Cancer: Focus on Optical Nano Biosensors

Background: Colorectal cancer is a leading cause of death among cancers worldwide, with the symptoms mimicking other far more common lower gastrointestinal disorders. Objective: This challenge in separating colorectal cancer from other diseases has driven researchers to investigate a noninvasive screening technique and effective method. The early detection of colorectal cancer is imperative. Biomarkers play a critical role in colorectal screening tests, treatment, clinical and prognosis management. Therefore, sensitive and rapid biomarker detection would be helpful and demand the early diagnosis of colorectal cancer. Methods: Recently, several investigations have been performed to design biosensors for early detection of cancer diagnosis and profiling with strong applied ability and high sensitivity. Results: In comparison, optical biosensors are one of the promising platforms for the costeffective and rapid detection of biomarkers. This review will focus on the advancements and progress of the various optical-transducing approaches for diagnosing colorectal cancer. Conclusion: Further, the prospects and limitations of these optical biosensors in colorectal cancer diagnosis will be discussed. Here, an overview of optical biosensors and meaningful information for scientists worldwide will be demonstrated.