Inhibition of Hypusine Biosynthesis in Plasmodium: A Possible, New Strategy in Prevention and Therapy of Malaria

A. Kaiser; D. Ulmer; T. Goebel; U. Holzgrabe; M. Saeftel; A. Hoerauf

doi:10.2174/138955706778742795

ISSN: 1389-5575
E-ISSN: 1875-5607

Inhibition of Hypusine Biosynthesis in Plasmodium: A Possible, New Strategy in Prevention and Therapy of Malaria
Authors: A. Kaiser¹, D. Ulmer², T. Goebel³, U. Holzgrabe⁴, M. Saeftel⁵ and A. Hoerauf⁶
View Affiliations Hide Affiliations

¹ Institute for Medical Parasitology,D-53105 Bonn, Germany. ² Institute for Medical Parasitology,D-53105 Bonn, Germany. ³ Institute for Medical Parasitology,D-53105 Bonn, Germany. ⁴ Institute for Medical Parasitology,D-53105 Bonn, Germany. ⁵ Institute for Medical Parasitology,D-53105 Bonn, Germany. ⁶ Institute for Medical Parasitology,D-53105 Bonn, Germany.
Source: Mini Reviews in Medicinal Chemistry, Volume 6, Issue 11, Nov 2006, p. 1231 - 1241
DOI: https://doi.org/10.2174/138955706778742795
- Available online: 01 Nov 2006

Abstract

The increasing drug resistance of malaria parasites against chemotherapeutics enforces new strategies in finding new drugs. Here, we describe a new class of compounds the piperidone 3-carboxylates which show an antiplasmodial effect in vitro and in vivo. This effect might be caused by inhibition of eukaryotic initiation factor (eIF-5A).

Article metrics loading...

/content/journals/mrmc/10.2174/138955706778742795

2006-11-01

2025-06-25

From This Site

/content/journals/mrmc/10.2174/138955706778742795

dcterms_title,dcterms_subject,pub_keyword

-contentType:Contributor -contentType:Concept -contentType:Institution

10

5

Full text loading...

/content/journals/mrmc/10.2174/138955706778742795

Article Type: Research Article

Keyword(s): antiplasmodial; deoxyhypusine synthase (DHS); dipyridyl-piperidone carbonic esters; Hypusine; initiation factor eIF-5A

Inhibition of Hypusine Biosynthesis in Plasmodium: A Possible, New Strategy in Prevention and Therapy of Malaria

Abstract

From This Site

Most Read This Month

Most Cited Most Cited RSS feed

Unequivocal Role of Pyrazine Ring in Medicinally Important Compounds: A Review

Imidazoles as Potential Antifungal Agents: A Review

Structure-Function Relationships in Chloroquine and Related 4-Aminoquinoline Antimalarials

Small Molecule Inhibitors of Serine Threonine Protein Phosphatases

DNA Tetraplex-Binding Drugs Structure-Selective Targeting is Critical for Antitumour Telomerase Inhibition

Nitric Oxide-Releasing Nonsteroidal Anti-inflammatory Drugs Novel Gastrointestinal-Sparing Drugs

Recent Advances in Bioreductive Drug Targeting

Structure-Metabolism Relationships Steric Effects and the Enzymatic Hydrolysis of Carboxylic Esters

Modifying TNF alpha for Therapeutic Use A Perspective on the TNF Receptor System

Recent Advances in the Synthesis of Tubulysins