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- ISSN: 1389-5575
- E-ISSN: 1875-5607
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Novel Strategies to Delineate Matrix Metalloproteinase (MMP)-Substrate Relationships and Identify Targets to Block MMP Activity
- Source: Mini Reviews in Medicinal Chemistry, Volume 6, Issue 11, Nov 2006, p. 1243 - 1248
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- 01 Nov 2006
Abstract
Adverse extracellular matrix (ECM) remodeling contributes to fibrotic disorders in the kidney, lung, and heart. Matrix metalloproteinases (MMPs) are key enzymes regulating ECM turnover, and MMP inhibition attenuates remodeling. Recent technological developments allow MMP-substrate relationships to be identified and explored as novel therapeutic targets. This review summarizes current and novel strategies to block MMP activity.
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