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- ISSN: 1389-5575
- E-ISSN: 1875-5607
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Antioxidative Actions of Statins: Potential Mechanisms for Antiathersclerotic Effects
- Source: Mini Reviews in Medicinal Chemistry, Volume 6, Issue 5, May 2006, p. 505 - 508
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- 01 May 2006
Abstract
Inhibitors of 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase (statins) are widely used for the prevention of atherosclerotic diseases. The effects of statins on the generation of reactive oxygen species (ROS) by in vitro and in vivo were studied. Administration of statins significantly decreased ROS generation in vitro and in vivo.
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