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- ISSN: 1389-5575
- E-ISSN: 1875-5607
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Regulatory T Cells in Cancer Biology: A Possible New Target for Biochemical Therapies
- Source: Mini Reviews in Medicinal Chemistry, Volume 6, Issue 5, May 2006, p. 509 - 513
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- 01 May 2006
Abstract
CD4+CD25+ T cells are essential for maintenance of self-tolerance and therefore have been referred to as regulatory T cells (Treg). Experimental tumor models revealed that Treg are potent inhibitors of an anti-tumor immune response. Treg are expanded in human cancer. Currently, a variety of strategies for the induction of a specific anti-tumor immune response are tested in preclinical and clinical settings. Biochemical strategies modifying and/or depleting Treg in cancer patients for an enhancement of vaccine-based therapeutic concepts will be discussed in detail in this review.
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