Recent Advances in Clarifying Prion Protein Functions Using Knockout Mice and Derived Cell Lines

Akikazu Sakudo; Takashi Onodera; Yoshikazu Suganuma; Takanori Kobayashi; Keiichi Saeki; Kazuyoshi Ikuta

doi:10.2174/138955706776876159

ISSN: 1389-5575
E-ISSN: 1875-5607

Recent Advances in Clarifying Prion Protein Functions Using Knockout Mice and Derived Cell Lines
Authors: Akikazu Sakudo¹, Takashi Onodera², Yoshikazu Suganuma³, Takanori Kobayashi⁴, Keiichi Saeki⁵ and Kazuyoshi Ikuta⁶
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¹ Department of Virology, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan. ² Department of Virology, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan. ³ Department of Virology, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan. ⁴ Department of Virology, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan. ⁵ Department of Virology, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan. ⁶ Department of Virology, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
Source: Mini Reviews in Medicinal Chemistry, Volume 6, Issue 5, May 2006, p. 589 - 601
DOI: https://doi.org/10.2174/138955706776876159
- Available online: 01 May 2006

Abstract

Considerable information on the functions of prion protein (PrP) has been accumulated. One experimental approach is the use of PrP gene-knockout mice and derived cell lines. This approach has contributed to elucidating the functions of cellular prion protein (PrPC), such as its anti-oxidative and anti-apoptotic roles. This review will introduce the recent advances in prion biology made possible by the availability of these tools.

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2006-05-01

2025-06-24

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Article Type: Research Article

Keyword(s): apoptosis; oxidative stress; Prion protein; PrP-deficient cells; PrP-knockout mice

Recent Advances in Clarifying Prion Protein Functions Using Knockout Mice and Derived Cell Lines

Abstract

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