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Back to (non)-Basics: Recent Developments in Neutral and Charge- Balanced Glycosidase Inhibitors
- Source: Mini Reviews in Medicinal Chemistry, Volume 3, Issue 7, Nov 2003, p. 669 - 678
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- 01 Nov 2003
Abstract
Certain glycosidase inhibitors possess potent antiviral, antitumour and antidiabetic properties. Glyconic acid lactones, the earliest glycosidase inhibitors identified, have planar anomeric carbons that mimic the transition state of glycoside hydrolysis. Other classes include lactams, glycals, epoxides, halides and sulfonium ions, the latter based on the natural product salacinol from an antidiabetic herb.
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