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Recent Progress in the Design of Selectin Inhibitors
- Source: Mini Reviews in Medicinal Chemistry, Volume 3, Issue 7, Nov 2003, p. 679 - 687
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- 01 Nov 2003
Abstract
The selectins are a family of cell-adhesion proteins that mediate the early stages of leukocyte recruitment from the blood stream to sites of tissue damage through recognition of the carbohydrate epitope sialyl Lewis-x (sLe-x). Current development of small molecule based inhibitors of this process and their clinical potential to address numerous acute and chronic diseases are explored.
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