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Abstract

Citrus fruits are widely recognized not only for their refreshing taste but also for their rich content of bioactive compounds, including flavonoids, carotenoids, and essential oils. The molecular mechanisms through which citrus-derived compounds exert their effects highlight their antioxidant, anti-inflammatory, anticancer, and cardioprotective properties. Flavonoids, such as hesperidin and naringin, exhibit potent antioxidant and anti-inflammatory properties, reducing oxidative stress and inflammation-related diseases. Carotenoids like beta-cryptoxanthin and lutein offer protective effects against various cancers and support eye health. The essential oils, dominated by limonene, show promising anticancer, antimicrobial, and cardioprotective effects. The role of citrus bioactive in modulating metabolic pathways, improving immune function, and promoting gut health. Nanoformulation of citrus-based compounds involves the development of nanometer-scale formulations of active ingredients derived from citrus plants. These formulations show the promising effect of preventing and managing chronic diseases such as diabetes, cardiovascular diseases, and certain types of cancer. The bioavailability and metabolism of citrus bioactive, emphasizing the importance of food matrix interactions and individual variability. By exploring current research, it is easy to understand the health benefits of citrus fruits and their therapeutic potential in nutritional science and preventive medicine.

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2025-01-07
2025-07-15
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References

  1. Bhandari D.P. Poudel D.K. Satyal P. Khadayat K. Dhami S. Aryal D. Chaudhary P. Ghimire A. Parajuli N. Volatile compounds and antioxidant and antimicrobial activities of selected citrus essential oils originated from nepal. Molecules 2021 26 21 6683 10.3390/molecules26216683 34771092
    [Google Scholar]
  2. Manzur M. Luciardi M.C. Blázquez M.A. Alberto M.R. Cartagena E. Arena M.E. Citrus sinensis Essential Oils an Innovative Antioxidant and Antipathogenic Dual Strategy in Food Preservation against Spoliage Bacteria. Antioxidants 2023 12 2 246 10.3390/antiox12020246 36829805
    [Google Scholar]
  3. Busetta G. Ponte M. Barbera M. Alfonzo A. Ioppolo A. Maniaci G. Guarcello R. Francesca N. Palazzolo E. Bonanno A. Moschetti G. Settanni L. Gaglio R. Influence of Citrus Essential Oils on the Microbiological, Physicochemical and Antioxidant Properties of Primosale Cheese. Antioxidants 2022 11 10 2004 10.3390/antiox11102004 36290727
    [Google Scholar]
  4. Hejazi M. Grant J.H. Peterson E. Trade impact of maximum residue limits in fresh fruits and vegetables. Food Policy 2022 106 102203 10.1016/j.foodpol.2021.102203
    [Google Scholar]
  5. Ben Hsouna A. Sadaka C. Generalić Mekinić I. Garzoli S. Švarc-Gajić J. Rodrigues F. Morais S. Moreira M.M. Ferreira E. Spigno G. Brezo-Borjan T. Akacha B.B. Saad R.B. Delerue-Matos C. Mnif W. The Chemical Variability, Nutraceutical Value, and Food-Industry and Cosmetic Applications of Citrus Plants: A Critical Review. Antioxidants 2023 12 2 481 10.3390/antiox12020481 36830039
    [Google Scholar]
  6. Ali A.M. Gabbar M.A. Abdel-Twab S.M. Fahmy E.M. Ebaid H. Alhazza I.M. Ahmed O.M. Antidiabetic Potency, Antioxidant Effects, and Mode of Actions of Citrus reticulata Fruit Peel Hydroethanolic Extract, Hesperidin, and Quercetin in Nicotinamide/Streptozotocin-Induced Wistar Diabetic Rats. Oxid. Med. Cell. Longev. 2020 2020 1 21 10.1155/2020/1730492 32655759
    [Google Scholar]
  7. Maqbool Z. Khalid W. Atiq H.T. Koraqi H. Javaid Z. Alhag S.K. Al-Shuraym L.A. Bader D.M.D. Almarzuq M. Afifi M. AL-Farga A. Citrus Waste as Source of Bioactive Compounds: Extraction and Utilization in Health and Food Industry. Molecules 2023 28 4 1636 10.3390/molecules28041636 36838623
    [Google Scholar]
  8. Ramírez-Guzmán N. Chávez-González M.L. Peña-Lucio E. Luna-García H.A. Valdés J.A.A. Martínez-Medina G. Citrus Waste: An Important Source of Bioactive Compounds. Bioprocess. Agri-Food Residues Prod. Bioprod 2021 61 80 10.1201/9781003048305‑3
    [Google Scholar]
  9. Šafranko S. Šubarić D. Jerković I. Jokić S. Citrus By-Products as a Valuable Source of Biologically Active Compounds with Promising Pharmaceutical, Biological and Biomedical Potential. Pharmaceuticals (Basel) 2023 16 8 1081 10.3390/ph16081081 37630996
    [Google Scholar]
  10. Singh B. Singh J.P. Kaur A. Singh N. Phenolic composition, antioxidant potential and health benefits of citrus peel. Food Res. Int. 2020 132 109114 10.1016/j.foodres.2020.109114 32331689
    [Google Scholar]
  11. Guo C. Shan Y. Yang Z. Zhang L. Ling W. Liang Y. Ouyang Z. Zhong B. Zhang J. Chemical composition, antioxidant, antibacterial, and tyrosinase inhibition activity of extracts from Newhall navel orange (Citrus sinensis Osbeck cv. Newhall) peel. J. Sci. Food Agric. 2020 100 6 2664 2674 10.1002/jsfa.10297 31997352
    [Google Scholar]
  12. Shehata M.G. Awad T.S. Asker D. El Sohaimy S.A. Abd El- Aziz N.M. Youssef M.M. Antioxidant and antimicrobial activities and UPLC-ESI-MS/MS polyphenolic profile of sweet orange peel extracts. Current Research in Food Science 2021 4 326 335 10.1016/j.crfs.2021.05.001 34124691
    [Google Scholar]
  13. Duletić-Laušević S. Oalđe M. Alimpić-Aradski A. In vitro evaluation of antioxidant, antineurodegenerative and antidiabetic activities of Ocimum basilicum L., Laurus nobilis L. leaves and Citrus reticulata Blanco peel extracts. Lek Sirovine 2019 60 68 10.5937/leksir1939060D
    [Google Scholar]
  14. Lin X. Cao S. Sun J. Lu D. Zhong B. Chun J. The chemical compositions, and antibacterial and antioxidant activities of four types of citrus essential oils. Molecules 2021 26 11 3412 10.3390/molecules26113412 34199966
    [Google Scholar]
  15. Maoka T. Carotenoids as natural functional pigments. J. Nat. Med. 2020 74 1 1 16 10.1007/s11418‑019‑01364‑x 31588965
    [Google Scholar]
  16. Metibemu D.S. Ogungbe I.V. Carotenoids in Drug Discovery and Medicine: Pathways and Molecular Targets Implicated in Human Diseases. Molecules 2022 27 18 6005 10.3390/molecules27186005 36144741
    [Google Scholar]
  17. Perera C.O. Yen G.M. Functional properties of carotenoids in human health. Int. J. Food Prop. 2007 10 2 201 230 10.1080/10942910601045271
    [Google Scholar]
  18. Saini R.K. Ranjit A. Sharma K. Prasad P. Shang X. Gowda K.G.M. Keum Y.S. Bioactive Compounds of Citrus Fruits: A Review of Composition and Health Benefits of Carotenoids, Flavonoids, Limonoids, and Terpenes. Antioxidants 2022 11 2 239 10.3390/antiox11020239 35204122
    [Google Scholar]
  19. Crupi P. Faienza M.F. Naeem M.Y. Corbo F. Clodoveo M.L. Muraglia M. Overview of the Potential Beneficial Effects of Carotenoids on Consumer Health and Well-Being. Antioxidants 2023 12 5 1069 10.3390/antiox12051069 37237935
    [Google Scholar]
  20. Ullah A. Munir S. Badshah S.L. Khan N. Ghani L. Poulson B.G. Emwas A.H. Jaremko M. Important flavonoids and their role as a therapeutic agent. Molecules 2020 25 22 5243 10.3390/molecules25225243 33187049
    [Google Scholar]
  21. Mutha R.E. Tatiya A.U. Surana S.J. Flavonoids as natural phenolic compounds and their role in therapeutics: an overview. Future Journal of Pharmaceutical Sciences 2021 7 1 25 10.1186/s43094‑020‑00161‑8 33495733
    [Google Scholar]
  22. Xiong H.H. Lin S.Y. Chen L.L. Ouyang K.H. Wang W.J. The Interaction between Flavonoids and Intestinal Microbes: A Review. Foods 2023 12 2 320 10.3390/foods12020320 36673411
    [Google Scholar]
  23. Addi M. Elbouzidi A. Abid M. Tungmunnithum D. Elamrani A. Hano C. An Overview of Bioactive Flavonoids from Citrus Fruits. Appl. Sci. (Basel) 2021 12 1 29 10.3390/app12010029
    [Google Scholar]
  24. Shah A. Smith D.L. Flavonoids in agriculture: Chemistry and roles in, biotic and abiotic stress responses, and microbial associations. Agronomy (Basel) 2020 10 8 1209 10.3390/agronomy10081209
    [Google Scholar]
  25. Li P. Yao X. Zhou Q. Meng X. Zhou T. Gu Q. Citrus Peel Flavonoid Extracts: Health-Beneficial Bioactivities and Regulation of Intestinal Microecology in vitro. Front. Nutr. 2022 9 888745 10.3389/fnut.2022.888745 35685878
    [Google Scholar]
  26. Zhuang W.B. Li Y.H. Shu X.C. Pu Y.T. Wang X.J. Wang T. Wang Z. The Classification, Molecular Structure and Biological Biosynthesis of Flavonoids, and Their Roles in Biotic and Abiotic Stresses. Molecules 2023 28 8 3599 10.3390/molecules28083599 37110833
    [Google Scholar]
  27. Masyita A. Mustika Sari R. Dwi Astuti A. Yasir B. Rahma Rumata N. Emran T.B. Nainu F. Simal-Gandara J. Terpenes and terpenoids as main bioactive compounds of essential oils, their roles in human health and potential application as natural food preservatives. Food Chem. X 2022 13 100217 10.1016/j.fochx.2022.100217 35498985
    [Google Scholar]
  28. Ninkuu V. Zhang L. Yan J. Fu Z. Yang T. Zeng H. Biochemistry of terpenes and recent advances in plant protection. Int. J. Mol. Sci. 2021 22 11 5710 10.3390/ijms22115710 34071919
    [Google Scholar]
  29. Zielińska-Błajet M. Feder-Kubis J. Monoterpenes and their derivatives—recent development in biological and medical applications. Int. J. Mol. Sci. 2020 21 19 7078 10.3390/ijms21197078 32992914
    [Google Scholar]
  30. Proshkina E. Plyusnin S. Babak T. Lashmanova E. Maganova F. Koval L. Platonova E. Shaposhnikov M. Moskalev A. Terpenoids as potential geroprotectors. Antioxidants 2020 9 6 529 10.3390/antiox9060529 32560451
    [Google Scholar]
  31. Avila C. Terpenoids in marine heterobranch molluscs. Mar. Drugs 2020 18 3 162 10.3390/md18030162 32183298
    [Google Scholar]
  32. Forestier E. Romero-Segura C. Pateraki I. Centeno E. Compagnon V. Preiss M. Berna A. Boronat A. Bach T.J. Darnet S. Schaller H. Distinct triterpene synthases in the laticifers of Euphorbia lathyris. Sci. Rep. 2019 9 1 4840 10.1038/s41598‑019‑40905‑y 30886213
    [Google Scholar]
  33. Ribeiro D. Sousa A. Nicola P. Ferreira de Oliveira J.M.P. Rufino A.T. Silva M. Freitas M. Carvalho F. Fernandes E. β-Carotene and its physiological metabolites: Effects on oxidative status regulation and genotoxicity in in vitro models. Food Chem. Toxicol. 2020 141 111392 10.1016/j.fct.2020.111392 32360219
    [Google Scholar]
  34. Adenaike O. Abakpa G.O. Antioxidant Compounds and Health Benefits of Citrus Fruits. Eur. J. Nutr. Food Saf. 2021 ••• 65 74 10.9734/ejnfs/2021/v13i230376
    [Google Scholar]
  35. Čižmárová B. Hubková B. Tomečková V. Birková A. Flavonoids as Promising Natural Compounds in the Prevention and Treatment of Selected Skin Diseases. Int. J. Mol. Sci. 2023 24 7 6324 10.3390/ijms24076324 37047297
    [Google Scholar]
  36. Richa R. Kohli D. Vishwakarma D. Mishra A. Kabdal B. Kothakota A. Richa S. Sirohi R. Kumar R. Naik B. Citrus fruit: Classification, value addition, nutritional and medicinal values, and relation with pandemic and hidden hunger. Journal of Agriculture and Food Research 2023 14 100718 10.1016/j.jafr.2023.100718
    [Google Scholar]
  37. Oregon State University Vitamin C and Skin Health | Linus Pauling Institute | Oregon State University. Linus Pauling Inst 2021
    [Google Scholar]
  38. Klimek-Szczykutowicz M. Szopa A. Ekiert H. Citrus limon (Lemon) phenomenon—a review of the chemistry, pharmacological properties, applications in the modern pharmaceutical, food, and cosmetics industries, and biotechnological studies. Plants 2020 9 1 119 10.3390/plants9010119 31963590
    [Google Scholar]
  39. Malinowska P. Antioxidant Activity of Fruit Extracts Used in Cosmetic Products. Curr Trends Commod Sci 2016 63 109 124
    [Google Scholar]
  40. Jahan F. Happy A.A. Revolutionizing plant-based extracts for skin care and therapeutics. 2022 10.1016/B978‑0‑12‑822967‑5.00010‑2
    [Google Scholar]
  41. Sander M. Sander M. Burbidge T. Beecker J. The efficacy and safety of sunscreen use for the prevention of skin cancer. CMAJ 2020 192 50 E1802 E1808 10.1503/cmaj.201085 33318091
    [Google Scholar]
  42. Gupta S. Rahman M.A. Sundaram S. Journal of Science and Healthcare Exploration (JSHE) CITRUS FRUIT AS A POTENTIAL SOURCE OF PHYTOCHEMICAL, ANTIOXIDANT AND PHARMACOLOGICAL INGREDIENTS. Peer-Reviewed, Ref Index Int Res J Impact Factor 2021 3
    [Google Scholar]
  43. Karasawa M.M.G. Mohan C. Fruits as Prospective Reserves of bioactive Compounds: A Review. Nat. Prod. Bioprospect. 2018 8 5 335 346 10.1007/s13659‑018‑0186‑6 30069678
    [Google Scholar]
  44. Panwar D. Saini A. Panesar P.S. Chopra H.K. Unraveling the scientific perspectives of citrus by-products utilization: Progress towards circular economy. Trends Food Sci. Technol. 2021 111 549 562 10.1016/j.tifs.2021.03.018
    [Google Scholar]
  45. Nimita G.N.V.G.K.S. Vikanksha Singh J. Composition of Bioactive Carotenoid, Flavonoid, and Terpene compounds in Selected Fruits: A Mini Review. Int. J. Plant Soil Sci. 2023 35 7 52 58 10.9734/ijpss/2023/v35i72861
    [Google Scholar]
  46. Liu S. Lou Y. Li Y. Zhang J. Li P. Yang B. Gu Q. Review of phytochemical and nutritional characteristics and food applications of Citrus L. fruits. Front. Nutr. 2022 9 968604 10.3389/fnut.2022.968604 35923210
    [Google Scholar]
  47. Majdan M. Bobrowska-Korczak B. Active Compounds in Fruits and Inflammation in the Body. Nutrients 2022 14 12 2496 10.3390/nu14122496 35745226
    [Google Scholar]
  48. Koolaji N. Shammugasamy B. Schindeler A. Dong Q. Dehghani F. Valtchev P. Citrus Peel Flavonoids as Potential Cancer Prevention Agents. Curr. Dev. Nutr. 2020 4 5 nzaa025 10.1093/cdn/nzaa025 32391511
    [Google Scholar]
  49. Hoenen M. Müller K. Pause B.M. Lübke K.T. Fancy Citrus, Feel Good: Positive Judgment of Citrus Odor, but Not the Odor Itself, Is Associated with Elevated Mood during Experienced Helplessness. Front. Psychol. 2016 7 74 10.3389/fpsyg.2016.00074 26869973
    [Google Scholar]
  50. Mohammadpourhodki R. Sadeghnezhad H. Ebrahimi H. Basirinezhad M.H. Maleki M. Bossola M. The Effect of Aromatherapy Massage With Lavender and Citrus Aurantium Essential Oil on Quality of Life of Patients on Chronic Hemodialysis: A Parallel Randomized Clinical Trial Study. J. Pain Symptom Manage. 2021 61 3 456 463.e1 10.1016/j.jpainsymman.2020.08.032 32889038
    [Google Scholar]
  51. Agarwal P. Sebghatollahi Z. Kamal M. Dhyani A. Shrivastava A. Singh K.K. Sinha M. Mahato N. Mishra A.K. Baek K.H. Citrus Essential Oils in Aromatherapy: Therapeutic Effects and Mechanisms. Antioxidants 2022 11 12 2374 10.3390/antiox11122374 36552586
    [Google Scholar]
  52. Mohammadi F. Moradi M. Niazi A. Jamali J. The Impact of Aromatherapy with Citrus Aurantium Essential Oil on Sleep Quality in Pregnant Women with Sleep Disorders: A Randomized Controlled Clinical Trial. Int. J. Community Based Nurs. Midwifery 2022 10 3 160 171 10.30476/IJCBNM.2022.92696.1900 35855386
    [Google Scholar]
  53. Yang J. Lee S.Y. Jang S.K. Kim K.J. Park M.J. Anti-Inflammatory Effects of Essential Oils from the Peels of Citrus Cultivars. Pharmaceutics 2023 15 6 1595 10.3390/pharmaceutics15061595 37376044
    [Google Scholar]
  54. Michalak M. Aromatherapy and Methods of Applying Essential Oils. Arch Physiother Glob Res 2018 22 25 31
    [Google Scholar]
  55. Mannucci C. Calapai F. Cardia L. Inferrera G. D’Arena G. Di Pietro M. Navarra M. Gangemi S. Ventura Spagnolo E. Calapai G. Clinical pharmacology of citrus aurantium and citrus sinensis for the treatment of anxiety. Evid. Based Complement. Alternat. Med. 2018 2018 1 3624094 10.1155/2018/3624094 30622597
    [Google Scholar]
  56. Holmes L. Cardiovascular Disease (CVD). Appl. Epigenomic Epidemiol. Essentials 2023 291 309 10.4324/9781003094487‑19
    [Google Scholar]
  57. Turner T. Burri B. Potential nutritional benefits of current citrus consumption. Agriculture 2013 3 1 170 187 10.3390/agriculture3010170
    [Google Scholar]
  58. Muller F.O. Re: The grapefruit: an old wine in a new glass? Metabolic and cardiovascular perspectives. Cardiovasc. J. Afr. 2011 22 1 37 21298205
    [Google Scholar]
  59. Ammar N. Hassan H. Abdallah H. Afifi S. Elgamal A. Farrag A. El-Gendy A. Farag M. Elshamy A. Protective Effects of Naringenin from Citrus sinensis (var. Valencia) Peels against CCl4-Induced Hepatic and Renal Injuries in Rats Assessed by Metabolomics, Histological and Biochemical Analyses. Nutrients 2022 14 4 841 10.3390/nu14040841 35215494
    [Google Scholar]
  60. Heidary Moghaddam R. Samimi Z. Moradi S.Z. Little P.J. Xu S. Farzaei M.H. Naringenin and naringin in cardiovascular disease prevention: A preclinical review. Eur. J. Pharmacol. 2020 887 173535 10.1016/j.ejphar.2020.173535 32910944
    [Google Scholar]
  61. Rizza S. Muniyappa R. Iantorno M. Kim J. Chen H. Pullikotil P. Senese N. Tesauro M. Lauro D. Cardillo C. Quon M.J. Citrus polyphenol hesperidin stimulates production of nitric oxide in endothelial cells while improving endothelial function and reducing inflammatory markers in patients with metabolic syndrome. J. Clin. Endocrinol. Metab. 2011 96 5 E782 E792 10.1210/jc.2010‑2879 21346065
    [Google Scholar]
  62. Barghouthy Y. Somani B.K. Role of citrus fruit juices in prevention of kidney stone disease (Ksd): A narrative review. Nutrients 2021 13 11 4117 10.3390/nu13114117 34836376
    [Google Scholar]
  63. Abou Baker D.H. Ibrahim B.M.M. Hassan N.S. Yousuf A.F. Gengaihi S.E. Exploiting Citrus aurantium seeds and their secondary metabolites in the management of Alzheimer disease. Toxicol. Rep. 2020 7 723 729 10.1016/j.toxrep.2020.06.001 32551234
    [Google Scholar]
  64. Maiuolo J. Gliozzi M. Carresi C. Musolino V. Oppedisano F. Scarano F. Nucera S. Scicchitano M. Bosco F. Macri R. Ruga S. Cardamone A. Coppoletta A. Mollace A. Cognetti F. Mollace V. Nutraceuticals and cancer: Potential for natural polyphenols. Nutrients 2021 13 11 3834 10.3390/nu13113834 34836091
    [Google Scholar]
  65. Leporini M. Tundis R. Sicari V. Loizzo M.R. Citrus species: Modern functional food and nutraceutical-based product ingredient. Ital. J. Food Sci. 2021 33 2 63 107 10.15586/ijfs.v33i2.2009
    [Google Scholar]
  66. Herdiana Y. Functional Food in Relation to Gastroesophageal Reflux Disease (GERD). Nutrients 2023 15 16 3583 10.3390/nu15163583 37630773
    [Google Scholar]
  67. Pasdaran A. Hamedi A. Shiehzadeh S. Hamedi A. A review of citrus plants as functional foods and dietary supplements for human health, with an emphasis on meta-analyses, clinical trials, and their chemical composition. Clin. Nutr. ESPEN 2023 54 311 336 10.1016/j.clnesp.2023.02.001 36963879
    [Google Scholar]
  68. Lobo V. Patil A. Phatak A. Chandra N. Free radicals, antioxidants and functional foods: Impact on human health. Pharmacogn. Rev. 2010 4 8 118 126 10.4103/0973‑7847.70902 22228951
    [Google Scholar]
  69. Yusuf K. Saha S. Umar S. Health Benefits of Dietary Fiber for the Management of Inflammatory Bowel Disease. Biomedicines 2022 10 6 1242 10.3390/biomedicines10061242 35740264
    [Google Scholar]
  70. Fam V.W. Charoenwoodhipong P. Sivamani R.K. Holt R.R. Keen C.L. Hackman R.M. Plant-Based Foods for Skin Health: A Narrative Review. J. Acad. Nutr. Diet. 2022 122 3 614 629 10.1016/j.jand.2021.10.024 34728412
    [Google Scholar]
  71. Ahmed H. Aboul-Enein A. abou-Elella F. Salem S. Aly H. Nassrallah A. Salama Z. Nano-formulations of hesperidin and essential oil extracted from sweet orange peel: Chemical Properties and Biological Activities. Egypt. J. Chem. 2021 0 0 0 10.21608/ejchem.2021.84783.4139
    [Google Scholar]
  72. Campolo O. Cherif A. Ricupero M. Siscaro G. Grissa-Lebdi K. Russo A. Cucci L.M. Di Pietro P. Satriano C. Desneux N. Biondi A. Zappalà L. Palmeri V. Citrus peel essential oil nanoformulations to control the tomato borer, Tuta absoluta: chemical properties and biological activity. Sci. Rep. 2017 7 1 13036 10.1038/s41598‑017‑13413‑0 29026207
    [Google Scholar]
  73. Das S. Vishakha K. Banerjee S. Mondal S. Ganguli A. Sodium alginate-based edible coating containing nanoemulsion of Citrus sinensis essential oil eradicates planktonic and sessile cells of food-borne pathogens and increased quality attributes of tomatoes. Int. J. Biol. Macromol. 2020 162 1770 1779 10.1016/j.ijbiomac.2020.08.086 32810536
    [Google Scholar]
  74. Mahdi A.A. Al-Maqtari Q.A. Mohammed J.K. Al-Ansi W. Cui H. Lin L. Enhancement of antioxidant activity, antifungal activity, and oxidation stability of Citrus reticulata essential oil nanocapsules by clove and cinnamon essential oils. Food Biosci. 2021 43 101226 10.1016/j.fbio.2021.101226
    [Google Scholar]
  75. Khane Y. Benouis K. Albukhaty S. Sulaiman G.M. Abomughaid M.M. Al Ali A. Aouf D. Fenniche F. Khane S. Chaibi W. Henni A. Bouras H.D. Dizge N. Green Synthesis of Silver Nanoparticles Using Aqueous Citrus limon Zest Extract: Characterization and Evaluation of Their Antioxidant and Antimicrobial Properties. Nanomaterials (Basel) 2022 12 12 2013 10.3390/nano12122013 35745352
    [Google Scholar]
  76. Makki H.J. Chandrasekharaiah K.S. Synthesis and Characterization of Citrus limonum Copper Nanoparticles and its in vitro Evaluation of Cytotoxicity against JURKAT Cells. Pharmacogn. Mag. 2023 19 3 499 508 10.1177/09731296231177492
    [Google Scholar]
  77. Alipanah H. Farjam M. Zarenezhad E. Roozitalab G. Osanloo M. Chitosan nanoparticles containing limonene and limonene-rich essential oils: potential phytotherapy agents for the treatment of melanoma and breast cancers. BMC Complementary Medicine and Therapies 2021 21 1 186 10.1186/s12906‑021‑03362‑7 34215240
    [Google Scholar]
  78. Amer R.I. Ezzat S.M. Aborehab N.M. Ragab M.F. Mohamed D. Hashad A. Attia D. Salama M.M. El Bishbishy M.H. Downregulation of MMP1 expression mediates the anti-aging activity of Citrus sinensis peel extract nanoformulation in UV induced photoaging in mice. Biomed. Pharmacother. 2021 138 111537 10.1016/j.biopha.2021.111537 34311535
    [Google Scholar]
  79. Yang C. Powell C.A. Duan Y. Shatters R. Zhang M. Antimicrobial nanoemulsion formulation with improved penetration of foliar spray through citrus leaf cuticles to control citrus huanglongbing. PLoS One 2015 10 7 e0133826 10.1371/journal.pone.0133826 26207823
    [Google Scholar]
  80. Rafi Z. Khan S. Sherwani S. Alshammari E.M. Khan M. Alshammari B.F. Ali Khan M.W. Anjum R. Khan M.Y. Ahmad N. Kaur K. Shahab U. Ahmad S. Citrus sinensis Seed-Mediated Gold Nanoparticles for Combating Diabetes and Bacterial Infections: A Promising Multifunctional Nano Formulation. Sci. Adv. Mater. 2024 16 2 260 270 10.1166/sam.2024.4634
    [Google Scholar]
  81. Prommaban A. Chaiyana W. Microemulsion of essential oils from citrus peels and leaves with anti-aging, whitening, and irritation reducing capacity. J. Drug Deliv. Sci. Technol. 2022 69 103188 10.1016/j.jddst.2022.103188
    [Google Scholar]
  82. Maurya A.K. Mohanty S. Pal A. Chanotiya C.S. Bawankule D.U. The essential oil from Citrus limetta Risso peels alleviates skin inflammation: In-vitro and in-vivo study. J. Ethnopharmacol. 2018 212 86 94 10.1016/j.jep.2017.10.018 29055721
    [Google Scholar]
  83. Anticancer and Cholesterol-Lowering Activities of Citrus Flavonoids Handb. Nutraceuticals Funct. Foods. CRC Press 2020 135 148 10.1201/9781420036695‑13
    [Google Scholar]
  84. Gupta A.K. Dhua S. Sahu P.P. Abate G. Mishra P. Mastinu A. Variation in phytochemical, antioxidant and volatile composition of pomelo fruit (Citrus grandis (l.) osbeck) during seasonal growth and development. Plants 2021 10 9 1941 10.3390/plants10091941 34579472
    [Google Scholar]
  85. Geraci A. Di Stefano V. Di Martino E. Schillaci D. Schicchi R. Essential oil components of orange peels and antimicrobial activity. Nat. Prod. Res. 2017 31 6 653 659 10.1080/14786419.2016.1219860 27535797
    [Google Scholar]
  86. Method for improving quality of citrus fruits by covering moisture-permeable mulching film to control water and application. Patent CN114375748A, 2021
  87. Anti-viral composition comprising fermentation product of fruit of genus citrus as active ingredient. Patent , 2015
  88. Citrus flavor beverage and method for producing citrus flavor beverage. Patent NCT04620200, 2021
  89. Method for simultaneously detecting content of 12 phenolic acids in citrus fruits. Patent NCT04620200, 2022
  90. Drying method and application of citrus olives. Patent NCT04620200, 2021
  91. An aqueous solution for treating nefrolithiasis comprising active ingredients from citrus fruits of the genus Citrus (Citrus limonum, Citrus aurantifolia) in the family Rutaceae and of the leaves of seagrape (Coccoloba uvifera) Patent EP2319522A1, n.d.
  92. Gibberellin-treated citrus fruit and method for preserving citrus fruit. Patent NCT04620200, 2009
  93. Application of lemon extract in improving vitamin E content of citrus fruits. Patent NCT04620200, 2021
/content/journals/mns/10.2174/0118764029343169241216042246
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  • Article Type:
    Review Article
Keywords: Nanotechnology ; Aromatherapy ; Citrus ; Nutraceuticals ; Antioxidant ; Flavonoids
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