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- ISSN: 1573-4064
- E-ISSN: 1875-6638
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LYP3, a New Bestatin Derivative for Aminopeptidase N Inhibition
- Source: Medicinal Chemistry, Volume 7, Issue 1, Jan 2011, p. 32 - 36
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- 01 Jan 2011
Abstract
Aminopeptidase N (APN) is a ubiquitous enzyme overexpressed on tumor cells and plays an important role in angiogenesis and metastasis of tumor. Bestatin as an effective inhibitor of aminopeptidase N is used for complementary treatment of cancer with other drugs. In this work, we reformed the structure of bestatin to a new derivative LYP3 to improve the water solubility and effectiveness. The inhibitory activity of LYP3 against APN was evaluated in vitro.
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