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image of Imidazole-Based Metal Complex Derivatives: A Comprehensive Overview of Synthesis and Biological Applications

Abstract

The imidazole scaffold is a cornerstone in medicinal chemistry, widely recognized for its extensive range of biological activities and ability to form stable metal complexes. This review article provides a detailed overview of recent advancements in synthesizing, characterization, and biological evaluation of metal-complexed imidazole derivatives. We explored various synthetic strategies to create diverse metal-based imidazole complexes, emphasizing innovations that enhance efficiency and yield. Furthermore, we delve into the biological profiling of imidazole derivatives, summarizing key findings from studies investigating their antimicrobial, antifungal, anticancer, and other therapeutic properties. Special attention is given to metal coordination's role in modulating these compounds' biological activity. The review discusses the synthesis of imidazole-metal complexes, illustrating how metal ions such as copper, zinc, and iron enhance the pharmacological profiles of imidazole derivatives. Thus, the data from numerous studies was collated and analyzed to comprehensively understand the current landscape and future prospects in imidazole chemistry associated with metals. It is a valuable resource for researchers, guiding future investigations and fostering the development of novel metal-based imidazole therapeutics.

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2024-10-30
2025-04-19

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References

  1. Patel G. Dewangan D.K. Bhakat N. Banerjee S. Green approaches for the synthesis of poly-functionalized imidazole derivatives: A comprehensive review. Current Research in Green and Sustainable Chemistry 2021 4 100175 10.1016/j.crgsc.2021.100175
    [Google Scholar]
  2. Liu H. Yang S. Li T. Ma S. Wang P. Wang G. Su S. Ding Y. Yang L. Zhou X. Yang S. Design, synthesis and bioactivity evaluation of novel 2-(pyrazol-4-yl)-1,3,4-oxadiazoles containing an Imidazole fragment as antibacterial agents. Molecules 2023 28 6 2442 10.3390/molecules28062442 36985415
    [Google Scholar]
  3. Jain A.K. Ravichandran V. Sisodiya M. Agrawal R.K. Synthesis and antibacterial evaluation of 2–substituted–4,5–diphenyl–N–alkyl imidazole derivatives. Asian Pac. J. Trop. Med. 2010 3 6 471 474 10.1016/S1995‑7645(10)60113‑7
    [Google Scholar]
  4. Ramachandran R. Rani M. Senthan S. Jeong Y.T. Kabilan S. Synthesis, spectral, crystal structure and in vitro antimicrobial evaluation of imidazole/benzotriazole substituted piperidin-4-one derivatives. Eur. J. Med. Chem. 2011 46 5 1926 1934 10.1016/j.ejmech.2011.02.036 21397368
    [Google Scholar]
  5. Bamoro C. Bamba F. Steve-Evanes K.T.D. Aurélie V. Vincent C. Design, synthesis and antibacterial activity evaluation of 4,5-Diphenyl-1<i>H</i>-imidazoles derivatives. Open J. Med. Chem. 2021 11 2 17 26 10.4236/ojmc.2021.112002
    [Google Scholar]
  6. Yang W.C. Li J. Li J. Chen Q. Yang G.F. Novel synthetic methods for N-cyano-1H-imidazole-4-carboxamides and their fungicidal activity. Bioorg. Med. Chem. Lett. 2012 22 3 1455 1458 10.1016/j.bmcl.2011.11.115 22189134
    [Google Scholar]
  7. Alkahtani H.M. Abbas A.Y. Wang S. Synthesis and biological evaluation of benzo[d]imidazole derivatives as potential anti-cancer agents. Bioorg. Med. Chem. Lett. 2012 22 3 1317 1321 10.1016/j.bmcl.2011.12.088 22225635
    [Google Scholar]
  8. Aruchamy B. Drago C. Russo V. Pitari G.M. Ramani P. Aneesh T.P. Benny S. Vishnu V.R. Imidazole-pyridine hybrids as potent anti-cancer agents. Eur. J. Pharm. Sci. 2023 180 106323 10.1016/j.ejps.2022.106323 36336277
    [Google Scholar]
  9. Pandey S. Tripathi P. Parashar P. Maurya V. Malik M.Z. Singh R. Yadav P. Tandon V. Synthesis and biological evaluation of Novel 1 H -Benzo[ d ]imidazole derivatives as potential anticancer agents targeting human topoisomerase I. ACS Omega 2022 7 3 2861 2880 10.1021/acsomega.1c05743 35097282
    [Google Scholar]
  10. Taheri B. Taghavi M. Zarei M. Chamkouri N. Mojaddami A. Imidazole and carbazole derivatives as potential anticancer agents: Molecular docking studies and cytotoxic activity evaluation. Bull. Chem. Soc. Ethiop. 2020 34 2 377 384 10.4314/bcse.v34i2.14
    [Google Scholar]
  11. Zhan P. Liu X. Zhu J. Fang Z. Li Z. Pannecouque C. Clercq E.D. Synthesis and biological evaluation of imidazole thioacetanilides as novel non-nucleoside HIV-1 reverse transcriptase inhibitors. Bioorg. Med. Chem. 2009 17 16 5775 5781 10.1016/j.bmc.2009.07.028 19643613
    [Google Scholar]
  12. Azimi S.G. Bagherzade G. Saberi M.R. Amiri Tehranizadeh Z. Discovery of new ligand with Quinoline Scaffold as potent allosteric inhibitor of HIV-1 and its copper complexes as a powerful catalyst for the synthesis of chiral Benzimidazole derivatives, and in Silico Anti-HIV-1 studies. Bioinorg. Chem. Appl. 2023 2023 1 17 10.1155/2023/2881582 37125145
    [Google Scholar]
  13. Patel H.M. Noolvi M.N. Sethi N.S. Gadad A.K. Cameotra S.S. Synthesis and antitubercular evaluation of imidazo[2,1- b ][1,3,4]thiadiazole derivatives. Arab. J. Chem. 2017 10 S996 S1002 10.1016/j.arabjc.2013.01.001
    [Google Scholar]
  14. Papadopoulou M.V. Bloomer W.D. Rosenzweig H.S. Arena A. Arrieta F. Rebolledo J.C.J. Smith D.K. Nitrotriazole- and imidazole-based amides and sulfonamides as antitubercular agents. Antimicrob. Agents Chemother. 2014 58 11 6828 6836 10.1128/AAC.03644‑14 25182645
    [Google Scholar]
  15. Nadaf A.A. Bulbule S.R. Yaseen M. Najare M.S. Mantur S. Khazi I.A.M. Synthesis of 1,2‐disubstituted Imidazole derivatives as potent inhibitors of Mycobacterium tuberculosis and their In Silico Studies. ChemistrySelect 2021 6 1 9 15 10.1002/slct.202003731
    [Google Scholar]
  16. Gising J. Nilsson M.T. Odell L.R. Yahiaoui S. Lindh M. Iyer H. Sinha A.M. Srinivasa B.R. Larhed M. Mowbray S.L. Karlén A. Trisubstituted imidazoles as Mycobacterium tuberculosis glutamine synthetase inhibitors. J. Med. Chem. 2012 55 6 2894 2898 10.1021/jm201212h 22369127
    [Google Scholar]
  17. Ali S. Ali M. Khan A. Ullah S. Waqas M. Al-Harrasi A. Latif A. Ahmad M. Saadiq M. Novel 5-(Arylideneamino)-1 H -Benzo[ d ]imidazole-2-thiols as potent anti-diabetic agents: Synthesis, In Vitro α-Glucosidase inhibition, and molecular docking studies. ACS Omega 2022 7 48 43468 43479 10.1021/acsomega.2c03854 36506132
    [Google Scholar]
  18. Adib M. Design and synthesis of new fused Carbazole-Imidazole derivatives as anti-diabetic agents: In Vitro α-Glucosidase inhibition, kinetic, and in Silico Studies Bioorganic Med. Chem. Lett. 2019 29 713 10.1016/j.bmcl.2019.01.012
    [Google Scholar]
  19. Saccoliti F. Madia V.N. Tudino V. De Leo A. Pescatori L. Messore A. De Vita D. Scipione L. Brun R. Kaiser M. Mäser P. Calvet C.M. Jennings G.K. Podust L.M. Pepe G. Cirilli R. Faggi C. Di Marco A. Battista M.R. Summa V. Costi R. Di Santo R. Design, synthesis, and biological evaluation of new 1-(Aryl-1 H -pyrrolyl)(phenyl)methyl-1 H -imidazole Derivatives as Antiprotozoal Agents. J. Med. Chem. 2019 62 3 1330 1347 10.1021/acs.jmedchem.8b01464 30615444
    [Google Scholar]
  20. Aguirre G. Boiani M. Cerecetto H. Gerpe A. González M. Sainz Y.F. Denicola A. de Ocáriz C.O. Nogal J.J. Montero D. Escario J.A. Novel antiprotozoal products: Imidazole and benzimidazole N-oxide derivatives and related compounds. Arch. Pharm. (Weinheim) 2004 337 5 259 270 10.1002/ardp.200300840 15095419
    [Google Scholar]
  21. Verma B. K. Kapoor S. Kumar U. Pandey S. Arya P. Synthesis of new Imidazole derivatives as effective antimicrobial agents Eur. J. Chem 2017 9 2018 10.30750/ijpbr.5.1.1
    [Google Scholar]
  22. Anupam A. Al-Bratty M. Alhazmi H.A. Ahmad S. Maity S. Alam M.S. Ahsan W. Synthesis and biological evaluation of triphenyl-imidazoles as a new class of antimicrobial agents. Eur. J. Chem. 2018 9 4 369 374 10.5155/eurjchem.9.4.369‑374.1785
    [Google Scholar]
  23. Awasthi A. Rahman M.A. Bhagavan Raju M. Synthesis, In Silico studies, and In Vitro anti-inflammatory activity of novel Imidazole derivatives targeting p38 MAP Kinase. ACS Omega 2023 8 20 17788 17799 10.1021/acsomega.3c00605 37251188
    [Google Scholar]
  24. Husain A. Drabu S. Kumar N. Alam M.M. Bawa S. Synthesis and biological evaluation of di- and tri-substituted imidazoles as safer anti-inflammatory-antifungal agents. J. Pharm. Bioallied Sci. 2013 5 2 154 161 10.4103/0975‑7406.111822 23833522
    [Google Scholar]
  25. Gaba M. Singh D. Singh S. Sharma V. Gaba P. Synthesis and pharmacological evaluation of novel 5-substituted-1-(phenylsulfonyl)-2-methylbenzimidazole derivatives as anti-inflammatory and analgesic agents. Eur. J. Med. Chem. 2010 45 6 2245 2249 10.1016/j.ejmech.2010.01.067 20172630
    [Google Scholar]
  26. Achar K.C.S. Hosamani K.M. Seetharamareddy H.R. In-vivo analgesic and anti-inflammatory activities of newly synthesized benzimidazole derivatives. Eur. J. Med. Chem. 2010 45 5 2048 2054 10.1016/j.ejmech.2010.01.029 20133024
    [Google Scholar]
  27. Hamdani H.E. Amane M.E. Preparation, spectral, antimicrobial properties and anticancer molecular docking studies of new metal complexes [M(caffeine)4] (PF6)2; M = Fe(II), Co(II), Mn(II), Cd(II), Zn(II), Cu(II), Ni(II). J. Mol. Struct. 2019 1184 262 270 10.1016/j.molstruc.2019.02.049
    [Google Scholar]
  28. Al-Hazmi G.A.A. Abou-Melha K.S. Althagafi I. El-Metwaly N. Shaaban F. Abdul Galil M.S. El-Bindary A.A. Synthesis and structural characterization of oxovanadium(IV) complexes of dimedone derivatives. Appl. Organomet. Chem. 2020 34 8 e5672 10.1002/aoc.5672
    [Google Scholar]
  29. El-Gammal O.A. Mohamed F.S. Rezk G.N. El-Bindary A.A. Synthesis, characterization, catalytic, DNA binding and antibacterial activities of Co(II), Ni(II) and Cu(II) complexes with new Schiff base ligand. J. Mol. Liq. 2021 326 115223 10.1016/j.molliq.2020.115223
    [Google Scholar]
  30. El-Gammal O.A. Mohamed F.S. Rezk G.N. El-Bindary A.A. Structural characterization and biological activity of a new metal complexes based of Schiff base. J. Mol. Liq. 2021 330 115522 10.1016/j.molliq.2021.115522
    [Google Scholar]
  31. Kongot M. Reddy D.S. Singh V. Patel R. Singhal N.K. Kumar A. Oxidovanadium (IV) and iron (III) complexes with O 2 N 2 donor linkage as plausible antidiabetic candidates: Synthesis, structural characterizations, glucose uptake and model biological media studies. Appl. Organomet. Chem. 2020 34 2 e5327 10.1002/aoc.5327
    [Google Scholar]
  32. Nagesh G.Y. Mahendra Raj K. Mruthyunjayaswamy B.H.M. Synthesis, characterization, thermal study and biological evaluation of Cu(II), Co(II), Ni(II) and Zn(II) complexes of Schiff base ligand containing thiazole moiety. J. Mol. Struct. 2015 1079 423 432 10.1016/j.molstruc.2014.09.013
    [Google Scholar]
  33. Siwach A. Verma P.K. Synthesis and therapeutic potential of imidazole containing compounds. BMC Chem. 2021 15 1 12 10.1186/s13065‑020‑00730‑1 33602331
    [Google Scholar]
  34. Verma A. Joshi S. Singh D. Imidazole: Having versatile biological activities. J. Chem. 2013 2013 1 329412 10.1155/2013/329412
    [Google Scholar]
  35. Tolomeu H.V. Fraga C.A.M. Imidazole: Synthesis, functionalization and physicochemical properties of a privileged structure in medicinal chemistry. Molecules 2023 28 2 838 10.3390/molecules28020838 36677894
    [Google Scholar]
  36. Jabbar H.S. Al-Edan A.K. Kadhum A.A.H. Roslam W.N. Sobri M. Synthesis and characterization of Imidazole derivatives and catalysis using chemical pharmaceutical compounds. J. Adv. Res. Dyn. Control Syst. 2019 11 1928
    [Google Scholar]
  37. Slassi S. Fix-Tailler A. Larcher G. Amine A. El-Ghayoury A. Imidazole and Azo-based Schiff bases ligands as highly active antifungal and antioxidant components 2019 10.1155/2019/6862170
    [Google Scholar]
  38. Bouchal B. Abrigach F. Takfaoui A. Elidrissi Errahhali M. Elidrissi Errahhali M. Dixneuf P.H. Doucet H. Touzani R. Bellaoui M. Identification of novel antifungal agents: Antimicrobial evaluation, SAR, ADME–Tox and molecular docking studies of a series of imidazole derivatives. BMC Chem. 2019 13 1 100 10.1186/s13065‑019‑0623‑6 31410411
    [Google Scholar]
  39. Ramachandran S. Panda M. Mukherjee K. Choudhury N.R. Tantry S.J. Kedari C.K. Ramachandran V. Sharma S. Ramya V.K. Guptha S. Sambandamurthy V.K. Synthesis and structure activity relationship of imidazo[1,2-a]pyridine-8-carboxamides as a novel antimycobacterial lead series. Bioorg. Med. Chem. Lett. 2013 23 17 4996 5001 10.1016/j.bmcl.2013.06.043 23867166
    [Google Scholar]
  40. Veerasamy R. Roy A. Karunakaran R. Rajak H. Structure–activity relationship analysis of Benzimidazoles as emerging anti-inflammatory agents: An Overview. Pharmaceuticals 2021 14 7 663 10.3390/ph14070663 34358089
    [Google Scholar]
  41. Poyraz S. Yıldırım M. Ersatir M. Recent pharmacological insights about imidazole hybrids: A comprehensive review. Med. Chem. Res. 2024 33 6 839 868 10.1007/s00044‑024‑03230‑2
    [Google Scholar]
  42. Saxer S. Marestin C. Mercier R. Dupuy J. The multicomponent Debus–Radziszewski reaction in macromolecular chemistry. Polym. Chem. 2018 9 15 1927 1933 10.1039/C8PY00173A
    [Google Scholar]
  43. Benincori T. Brenna E. Sannicolo F. Studies on Wallach’s imidazole synthesis. J. Chem. Soc., Perkin Trans. 1 1993 6 675 10.1039/p19930000675
    [Google Scholar]
  44. Bhatnagar A. Sharma P.K. Kumar N. A review on “Imidazoles”: Their chemistry and pharmacological potentials. Int. J. Pharm. Tech. Res. 2011 3 268
    [Google Scholar]
  45. Nalage S. Kalyankar M.B. Patil V.S. Bhosale S.V. Deshmukh S.U. Pawar R.P. An Efficient noncatalytic protocol for the synthesis of trisubstituted imidazole in polyethylene glycol using microwaves~!2009-11-14~!2010-03-10~!2010-09-16~! Open Catalysis Journal 2010 3 1 58 61 10.2174/1876214X01003010058
    [Google Scholar]
  46. Devi M.M. Devi K.S. Singh O.M. Singh T.P. Synthesis of imidazole derivatives in the last 5 years: An update. Heterocycl. Commun. 2024 30 1 20220173 10.1515/hc‑2022‑0173
    [Google Scholar]
  47. Alshehri N.S. Sharfalddin A.A. Domyati D. Basaleh A.S. Hussien M.A. Experiment versus theory of copper (II) complexes based imidazole derivatives as anti-cancer agents. J. Indian Chem. Soc. 2022 99 10 100692 10.1016/j.jics.2022.100692
    [Google Scholar]
  48. Selwin Joseyphus R. Reshma R. Arish D. Elumalai V. Antimicrobial, photocatalytic action and molecular docking studies of imidazole-based Schiff base complexes. Results Chem. 2022 4 100583 10.1016/j.rechem.2022.100583
    [Google Scholar]
  49. Sciences I.H. Integrated Health Sciences 2016 IV 26
    [Google Scholar]
  50. Abdulghani A.J. Hussain R.K. Synthesis and characterization of schiff base metal complexes derived from Cefotaxime with 1 H -Indole-2, 3-Dione (Isatin) And. Sch. Res. Libr. 2015 7 83
    [Google Scholar]
  51. Mahdi M.A. Jasim L.S. Mohamed M.H. Synthesis and anticancer activity evaluation of novel ligand 2- [2 - (5-Chloro Carboxy Phenyl) Azo] 1-Methyl Imidazole (1-Mecpai) with some metal complexes. Syst. Rev. Pharm. 2020 11 1979
    [Google Scholar]
  52. Saeed-ur-Rehman Synthesis, characterization and antimicrobial studies of transition metal complexes of Imidazole derivative Bull. Chem. Soc. Ethiop. 2010 24 201
    [Google Scholar]
  53. Radha V.P. Jone Kirubavathy S. Chitra S. Synthesis, characterization and biological investigations of novel Schiff base ligands containing imidazoline moiety and their Co(II) and Cu(II) complexes. J. Mol. Struct. 2018 1165 246 258 10.1016/j.molstruc.2018.03.109
    [Google Scholar]
  54. Nguyen V.T. Huynh T.K.C. Ho G.T.T. Nguyen T.H.A. Le Anh Nguyen T. Dao D.Q. Mai T.V.T. Huynh L.K. Hoang T.K.D. Metal complexes of benzimidazole-derived as potential anti-cancer agents: Synthesis, characterization, combined experimental and computational studies. R. Soc. Open Sci. 2022 9 9 220659 10.1098/rsos.220659 36147940
    [Google Scholar]
  55. Jawad S.H. Al-Adilee K.J. Synthesis and characterization of a new 1-methyl imidazole derived ligand with its ionic complexes Pd(II) and Pt(IV) and study of biological activity as anticancer and antioxidant. Results Chem. 2022 4 100573 10.1016/j.rechem.2022.100573
    [Google Scholar]
  56. Gomleksiz M. Alkan C. Erdem B. Synthesis, characterization and antibacterial activity of imidazole derivatives of 1,10-phenanthroline and their Cu(II), Co(II) and Ni(II) complexes. S. Afr. J. Chem. 2013 66 107
    [Google Scholar]
  57. Mohammed F. Synthesis and biological activity of some complexes of (2-Phenyl-4-Arylidine Imidazole- 5-One) with some transition metal ions Int. J. Adv. Res. (Indore) 2014 2 399
    [Google Scholar]
  58. Yahya W.I. Mgheed T.H. Kadhium A.J. Preparation, characterization of some metal complexes of new mixed ligands derived from 5-Methyl Imidazole and study the biological activity of Palladium (II) complex as Anticance. Neuroquantology 2022 20 1 71 83 10.14704/nq.2022.20.1.NQ22010
    [Google Scholar]
  59. Reshma R. Selwin Joseyphus R. Arish D. Reshmi Jaya R.J. Johnson J. Tridentate imidazole-based Schiff base metal complexes: Molecular docking, structural and biological studies. J. Biomol. Struct. Dyn. 2022 40 18 8602 8614 10.1080/07391102.2021.1914171 33896364
    [Google Scholar]
  60. Kadhium D.A.J. Abdulrasool R.N. synthesis and characterization some transition metal complexes of new ligand Chalcone-Azo derivatives from P-methoxy-4, 5-diphenyl Imidazole and study biological effect of Pd(II) complex. Neuroquantology 2022 20 3 173 181 10.14704/nq.2022.20.3.NQ22057
    [Google Scholar]
  61. Society C. 2013
  62. Selwin Joseyphus R. Shiju C. Joseph J. Justin Dhanaraj C. Arish D. Synthesis and characterization of metal complexes of Schiff base ligand derived from imidazole-2-carboxaldehyde and 4-aminoantipyrine. Spectrochim. Acta A Mol. Biomol. Spectrosc. 2014 133 149 155 10.1016/j.saa.2014.05.050 24934973
    [Google Scholar]
  63. Mol Joseph S. Justin Dhanaraj C. Joseph J. Selwin Joseyphus R. Synthesis, spectral characterization and anticancer studies of some metal(II) complexes derived from Imidazole-2-carboxaldehyde with 2-Amino-3-carboxyethyl-4,5-dimethylthiophene. Orient. J. Chem. 2017 33 3 1477 1482 10.13005/ojc/330351
    [Google Scholar]
  64. Eslami Moghadam M. Divsalar A. Abolhosseini Shahrnoy A. Saboury A.A. Synthesis, cytotoxicity assessment, and interaction and docking of novel palladium(II) complexes of imidazole derivatives with human serum albumin. J. Biomol. Struct. Dyn. 2016 34 8 1751 1762 10.1080/07391102.2015.1090345 26338667
    [Google Scholar]
  65. Selwin Joseyphus R. Sivasankaran Nair M. Synthesis, characterization and antimicrobial activity of transition metal complexes with the Schiff base derived from imidazole-2-carboxaldehyde and glycylglycine. J. Coord. Chem. 2009 62 2 319 327 10.1080/00958970802236048
    [Google Scholar]
  66. Yadav P. Sharma S. Kumari S. Ranka M. Mixed Ligand complex of monovalent copper with Benzimidazole derivatives and Alanine: Synthesis, characterization and antimicrobial studies. Indian J. Chem. Sect. A 2021 60 1539
    [Google Scholar]
  67. Rashed N. M. Abdullaha S. A. Synthesis, characterization and biological activity of mixed ligand complexes of some metal ions containing new 2- thioxoimidazolidine-4- one derivative and amino acid NVEO - Nat. VOLATILES Essent. OILS J. 2021 9004 9004
    [Google Scholar]
  68. Hussein M.B. Mohammed M.M. Sulfab Y. Synthesis, characterization and antimicrobial study of Pd(II) and Pt(II) complexes of 4-methyl-5-Imidazolecarboxaldehyde Thiosemicarbazone. Scholars International Journal of Chemistry and Material Sciences 2023 6 1 1 17 10.36348/sijcms.2023.v06i01.001
    [Google Scholar]
  69. Moghadam M.E. Divsalar A. Zare M.S. Gholizadeh R. Mahalleh D. Saghatforosh L. Sanati S. Anticancer, antibacterial and antifungal activity of new ni (ii) and cu (ii) complexes of imidazole-phenanthroline derivatives. Nucleosides Nucleotides Nucleic Acids 2017 36 11 667 675 10.1080/15257770.2017.1388393 29185856
    [Google Scholar]
  70. Kalinowska-Lis U. Szewczyk E.M. Chęcińska L. Wojciechowski J.M. Wolf W.M. Ochocki J. Synthesis, characterization, and antimicrobial activity of silver(I) and copper(II) complexes of phosphate derivatives of pyridine and benzimidazole. ChemMedChem 2014 9 1 169 176 10.1002/cmdc.201300333 24218046
    [Google Scholar]
  71. Kanthecha D.A. Bhatt B.S. Patel M.N. Synthesis, characterization and biological activities of imidazo[1,2-a]pyridine based gold(III) metal complexes. Heliyon 2019 5 6 e01968 10.1016/j.heliyon.2019.e01968 31294115
    [Google Scholar]
  72. Guo J.L. Liu G.Y. Wang R.Y. Sun S.X. Synthesis and structure elucidation of two essential metal complexes:In-Vitro studies of their BSA/HSA-binding properties, docking simulations, and anticancer activities. Molecules 2022 27 6 1886 10.3390/molecules27061886 35335248
    [Google Scholar]
  73. Ali F.J. Radhi E.R. Ali K.J. Synthesis and characterization of a new azo ligand derivative from 4,5-BIS(4-Methoxyphenyl) Imidazol and its metal complexes and biological activity study of its PD(II) complex. Pak. J. Med. Health Sci. 2022 16 7 431 434 10.53350/pjmhs22167431
    [Google Scholar]
  74. Al-Hadi B.A. Othman E.A. Karem L.K.A. Synthesis, characterization, and biological studies of new complexes derived from 2-(1H-Benzimidazol-2-Yl) Aniline. Int. J. Drug Deliv. Technol. 2021 11 937
    [Google Scholar]
  75. Al-Hakimi A.N. Alminderej F. Aroua L. Alhag S.K. Alfaifi M.Y. Design, synthesis, characterization of Zirconium (IV), Cadmium (II) and Iron (III) complexes derived from Schiff Base 2-Aminomethylbenzimidazole, 2-Hydroxynaphtadehyde and evaluation of their biological activity. Arab. J. Chem. 2020 13 7378 10.1016/j.arabjc.2020.08.014
    [Google Scholar]
  76. Suwalsky M. Castillo I. Sánchez-Eguía B.N. Gallardo M.J. Dukes N. Santiago-Osorio E. Aguiñiga I. Rivera-Martínez A.R. In vitro effects of benzimidazole/thioether-copper complexes with antitumor activity on human erythrocytes. J. Inorg. Biochem. 2018 178 87 93 10.1016/j.jinorgbio.2017.10.009 29121535
    [Google Scholar]
  77. Padalkar V.S. Patil V.S. Gupta V.D. Phatangare K.R. Umape P.G. Sekar N. Synthesis, characterization, thermal properties, and antimicrobial activities of 5-(Diethylamino)-2-(5-nitro-1 H -benzimidazol-2-yl)phenol and its transition metal complexes. ISRN Org. Chem. 2011 2011 1 7 10.5402/2011/738361 24052831
    [Google Scholar]
  78. Witwit I.N. Motaweq Z.Y. Mubark H.M. Synthesis, characterization, and biological efficacy on new mixed ligand complexes based from Azo Dye of 8-Hydroxy quinoline as a primary ligand and imidazole as a secondary ligand with some of transition metal ions. J. Pharm. Sci. Res. 2018 10 3074
    [Google Scholar]
  79. Quyoom S. Synthesis, characterization and antimicrobial studies of some mixed ligand ternary metal complexes. Int. J. Chem. Sci. 2013 11 1448
    [Google Scholar]
  80. Maru M.S. Shah M.K. Synthesis, characterization and antimicrobial evaluation of transition metal complexes of Monodentate 2-(Substituted Phenyl) -1H-Benzo[d]Imidazoles. Warasan Khana Witthayasat Maha Witthayalai Chiang Mai 2015 42 217
    [Google Scholar]
  81. Tirkeso R. A. Tsega T. W. Amdemichael G. G. T. Synthesis, characterization, and antibacterial activities of Ni ( II ) and Cu ( II ) complexes J. Chem. 2019 2019 7145857
    [Google Scholar]
  82. Abdoon S.N. Al-Obaidy S.S.M. Al-Khafaji Y.F. Synthesis, Spectral Analysis, Stability, Antibacterial, and Antioxidant of Fe(II) Mixed Ligands Complex of Imidazole and 1,10-Phenanthroline. J. Med. Chem. Sci. 2022 5 1231
    [Google Scholar]
  83. Pawar S. R. Sinkar S. N. Moharir S. P. Undegaonkar M. G. Mirgane S. R. Green Synthesis , characterization and biological activity study of transition metal complexes of schiff base ligand ( 19Z ) -N- ( 3- (( Z ) - ( 5 , 6-Dimethyl-1H 2018 8 300
    [Google Scholar]
  84. Abdullah S.A.H. Faeq R.I. Kadhem N.A. Mohsen S. Kadham S.A. Egypt. J. Chem. 2023 66 129
    [Google Scholar]
  85. Mallikarjun G. Synthesis, characterization and biological activity of schiff base metal complexes. Asian J. Res. Chem 2017 10 4 587 10.5958/0974‑4150.2017.00098.0
    [Google Scholar]
  86. Kalanithi M. Rajarajan M. Tharmaraj P. Synthesis, spectral, and biological studies of transition metal chelates of N-[1-(3-aminopropyl)imidazole]salicylaldimine. J. Coord. Chem. 2011 64 5 842 850 10.1080/00958972.2011.557432
    [Google Scholar]
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Imidazole-Based Metal Complex Derivatives: A Comprehensive Overview of Synthesis and Biological Applications
Bentham Science Publishers ; https://doi.org/10.2174/0115734064332208241015154509
/content/journals/mc/10.2174/0115734064332208241015154509
/content/journals/mc/10.2174/0115734064332208241015154509
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  • Article Type:     Review Article
Keywords: imidazole ; evaluating methods ; Biological activity ; metal complex

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