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Volume 20, Issue 9
  • ISSN: 1573-4064
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Abstract

One important class of organic compounds having many uses, especially in medical chemistry, is benzothiophene and its derivatives. This review examines the biological activity of benzothiophene derivatives and summarizes the synthetic methods used in their production. The effectiveness of several synthetic pathways, such as cyclization techniques, functional group modifications, and reactions catalyzed by transition metals, in gaining access to benzothiophene scaffolds has been examined. Additionally, a broad spectrum of therapeutic domains, such as anti-inflammatory, antibacterial, antidiabetic, anticancer, antimicrobial, anti-leishmanial, antifungal, antimalarial, and antitubercular activities, are covered by the pharmacological activities that are being explored. The synthesis and pharmacological potential of benzothiophene derivatives are well-explained in this thorough review, which opens up new options for medicinal chemistry and drug discovery study. Overall, this study is a useful resource for scientists working on drug development and discovery as it sheds light on the pharmacological potential of benzothiophene derivatives. This review includes the synthesis and bioactivities of the years 2002-2024. The goal of this review is to compile the existing information on benzothiophene derivatives and provide guidance for future research and development as well as insights into their possible medicinal uses.

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2024-06-10
2024-11-14

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References

  1. AgrawalN. BansalD. GautamV. Synthetic and pharmacological expedition of pyrazolo[1,5-a]pyridine: A comprehensive review.Lett. Drug Des. Discov.2024211718710.2174/1570180820666230803101948
     [Google Scholar]
  2. PathakS. JainS. PratapA. A review on synthesis and biological potential of dihydropyridines.Lett. Drug Des. Discov.2024211153310.2174/1570180820666230508100955
     [Google Scholar]
  3. AgrawalN. BhardwajA. An appraisal on synthetic and pharmaceutical perspectives of quinoxaline 1, 4‐DI‐ N ‐oxide scaffold.Chem. Biol. Drug Des.2022100334636310.1111/cbdd.14094 35610776
     [Google Scholar]
  4. AgrawalN. MishraP. Novel isoxazole derivatives as potential antiparkinson agents: Synthesis, evaluation of monoamine oxidase inhibitory activity and docking studies.Med. Chem. Res.20192891488150110.1007/s00044‑019‑02388‑4
     [Google Scholar]
  5. AgrawalN. GoswamiR. PathakS. Synthetic methods for various chromeno-fused heterocycles and their potential as antimicrobial agents.Med. Chem.202420211512910.2174/0115734064274748231005074100 37855281
     [Google Scholar]
  6. AgrawalN. MishraR. PathakS. GoyalA. ShahK. Hydrazides and hydrazones: Robust scaffolds in neurological and neurodegenerative disorders.Lett. Org. Chem.202320212313610.2174/1570178619666220831122614
     [Google Scholar]
  7. PanditN. ShahK. AgrawalN. UpmanyuN. ShrivastavaS.K. MishraP. Synthesis, characterization and biological evaluation of some novel fluoroquinolones.Med. Chem. Res.201625584385110.1007/s00044‑016‑1526‑x
     [Google Scholar]
  8. PathakS. AgrawalN. GaurS. A review on diverse biological activity of heterocyclic nucleus pyrazine and its derivatives: A key for the researchers.Lett. Org. Chem.202421435136110.2174/0115701786273932230927062616
     [Google Scholar]
  9. PathakS. SharmaR. A comprehensive review on the benzimidazole scaffold as a potential nucleus for anticancer activity.Lett. Org. Chem.202320980281710.2174/1570178620666230330105103
     [Google Scholar]
  10. PathakS. PandeyR. AgrawalN. Anilinopyrimidines: A review exploring synthetic approaches and biological activity.Lett. Org. Chem.2023201093194410.2174/1570178620666230525140626
     [Google Scholar]
  11. ZaniF. ViciniP. IncertiM. Synthesis and antimicrobial properties of 2-(benzylidene-amino)-benzo[d]isothiazol-3-ones.Eur. J. Med. Chem.200439213514010.1016/j.ejmech.2003.11.004 14987822
     [Google Scholar]
  12. YadavP. ShahK. Quinolines, a perpetual, multipurpose scaffold in medicinal chemistry.Bioorg. Chem.202110910463910.1016/j.bioorg.2021.104639 33618829
     [Google Scholar]
  13. YadavP. ShahK. Chemistry and biological evaluation of pyrido[4,3‐ d]pyrimidines: A review.Chem. Biol. Drug Des.202299575876810.1111/cbdd.14026 35152554
     [Google Scholar]
  14. VaidyaA. PathakD. ShahK. 1,3,4‐oxadiazole and its derivatives: A review on recent progress in anticancer activities.Chem. Biol. Drug Des.202197357259110.1111/cbdd.13795 32946168
     [Google Scholar]
  15. ChhabraS. ShahK. Synthesis and evaluation of cytotoxic activity of new analogues of 4‐substituted 1,2,4‐benzothiadiazine‐1,1‐dioxide.ChemistrySelect2023832e20230220410.1002/slct.202302204
     [Google Scholar]
  16. SahuR. ShahK. MalviyaR. PaliwalD. SagarS. SinghS. PrajapatiB.G. Recent advancement in pyrrolidine moiety for the management of cancer: A review.Results Chem.2024710130110.1016/j.rechem.2023.101301
     [Google Scholar]
  17. IslamS. HosenM.A. AhmadS. ul QamarM.T. DeyS. HasanI. FujiiY. OzekiY. KawsarS.M.A. Synthesis, antimicrobial, anticancer activities, PASS prediction, molecular docking, molecular dynamics and pharmacokinetic studies of designed methyl α-D-glucopyranoside esters.J. Mol. Struct.2022126013276110.1016/j.molstruc.2022.132761
     [Google Scholar]
  18. ViciniP. ZaniF. CozziniP. DoytchinovaI. Hydrazones of 1,2-benzisothiazole hydrazides: Synthesis, antimicrobial activity and QSAR investigations.Eur. J. Med. Chem.200237755356410.1016/S0223‑5234(02)01378‑8 12126774
     [Google Scholar]
  19. FakhrI.M.I. RadwanM.A.A. El-BatranS. Abd El-SalamO.M.E. El-ShenawyS.M. Synthesis and pharmacological evaluation of 2-substituted benzo[b]thiophenes as anti-inflammatory and analgesic agents.Eur. J. Med. Chem.20094441718172510.1016/j.ejmech.2008.02.034 18433939
     [Google Scholar]
  20. KumarA. ThoratK.G. RavikanthM. Benzofuran-/Benzothiophene-Incorporated NIR-Absorbing Triphyrins(2.1.1).Org. Lett.201820164871487410.1021/acs.orglett.8b02012 30067043
     [Google Scholar]
  21. OzokO. KavakE. KivrakA. Synthesis of novel artesunate-benzothiophene and artemisinin-benzothiophene derivatives.Nat. Prod. Res.202236205228523410.1080/14786419.2021.1928116 34024198
     [Google Scholar]
  22. LiT. LiJ. ZhangH. SunK. XiaoJ. DFT research on benzothiophene pyrolysis reaction mechanism.J. Phys. Chem. A2019123479681010.1021/acs.jpca.8b09882 30601656
     [Google Scholar]
  23. KeriR.S. ChandK. BudagumpiS. Balappa SomappaS. PatilS.A. NagarajaB.M. An overview of benzo [b] thiophene-based medicinal chemistry.Eur. J. Med. Chem.20171381002103310.1016/j.ejmech.2017.07.038 28759875
     [Google Scholar]
  24. PengT. ChenJ. LiuR. QuJ. A benzothiophene-based fluorescent probe with dual-functional to polarity and cyanide for practical applications in living cells and real water samples.Spectrochim. Acta A Mol. Biomol. Spectrosc.202431412419810.1016/j.saa.2024.124198 38552540
     [Google Scholar]
  25. NandanaS.K. Ann BabuS. JohnJ. HopfH. A review on the synthetic methods towards benzothienobenzothiophenes.Chem. Rec.202424e202400019
     [Google Scholar]
  26. RoyS. BudhathokiS. IqbalA.D. EricksonA.N. AliM.A. AlamM.A. Domino reaction protocol to synthesize benzothiophene-derived chemical entities as potential therapeutic agents.J. Org. Chem.20248963781379910.1021/acs.joc.3c02646 38408196
     [Google Scholar]
  27. Gallardo-MaciasR. RussoR. SherwoodM. JaskowskiM. NasserW. SharmaP. TuckmanM. SingletonE. HoH.P. ParkS. PatelJ.S. GeorgeA. PerlinD. ZimmermanM.D. ConnellN. FreundlichJ.S. Small molecule benzothiophene with in vivo efficacy in a mouse model of drug-resistant enterococcus faecium infection.J. Med. Chem.20246721384139210.1021/acs.jmedchem.3c01846 38225186
     [Google Scholar]
  28. ShafiqI. KhalidM. MariaG. RazaN. BragaA.A.C. BulloS. KhairyM. Use of benzothiophene ring to improve the photovoltaic efficacy of cyanopyridinone-based organic chromophores: A DFT study.RSC Advances20241418128411285210.1039/D3RA06817J 38645518
     [Google Scholar]
  29. LiuQ. MaL. ChenF. ZhangS. HuangZ. ZhengX. ChenZ. YeJ. HouN. YiW. ZhouZ. Raloxifene-driven benzothiophene derivatives: Discovery, structural refinement, and biological evaluation as potent PPARγ modulators based on drug repurposing.Eur. J. Med. Chem.202426911632510.1016/j.ejmech.2024.116325 38527378
     [Google Scholar]
  30. IwamotoH. KojimaY. NishimuraK. YasuiK. HiranoK. Direct synthesis of benzoselenophene and benzothiophene derivatives from 1,1-diarylethenes and biaryls by chalcogen cationmediated successive bond formation.Org. Lett.2024265acs.orglett.3c0403310.1021/acs.orglett.3c0403338277688
     [Google Scholar]
  31. ItoK. NakamuraK. YoshidaK. Synthesis of [1]Benzothieno[3,2‐ b][1]benzothiophenes through Iodine‐Mediated Sulfur Insertion Reaction.Chemistry20243021e20240022010.1002/chem.202400220 38320966
     [Google Scholar]
  32. FoudaA. NegiS. ZarembaO. GaidarR.S. MorozY.S. RusanovE. ParaskevasS. TchervenkovJ. Discovery, synthesis, and in vitro characterization of 2,3 derivatives of 4,5,6,7-tetrahydro-benzothiophene as potent modulators of retinoic acid receptor-related orphan receptor γt.J. Med. Chem.202366117355737310.1021/acs.jmedchem.3c00021 37172324
     [Google Scholar]
  33. BarbierT. BarbryA. MagandJ. BadiouC. DavyF. BaudouinA. QueneauY. DumitrescuO. LinaG. SoulèreL. Synthesis and biological evaluation of benzo[b]thiophene acylhydrazones as antimicrobial agents against multidrug-resistant Staphylococcus aureus.Biomolecules202212113110.3390/biom12010131 35053281
     [Google Scholar]
  34. BaiC. WuS. RenS. ZhuM. LuoG. XiangH. Benzothiophene derivatives as selective estrogen receptor covalent antagonists: Design, synthesis and anti-ERα activities.Bioorg. Med. Chem.20214711639510.1016/j.bmc.2021.116395 34509864
     [Google Scholar]
  35. DhanyaT.M. Anjali KrishnaG. SavithaD.P. ShantyA.A. DivyaK.M. PriyaS.K. MohananP.V. A review on the synthesis and biological relevance of benzo[ b]thiophene derivatives.Phosphorus Sulfur Silicon Relat. Elem.2023198428329910.1080/10426507.2022.2145476
     [Google Scholar]
  36. KawamotoY. TominoM. HiramatsuK. OyamaY. HayashiY. Benzothiophene derivatives as phosphodiesterase 10A (PDE10A) inhibitors: Hit-to-lead studies.Bioorg. Med. Chem. Lett.201929111419142210.1016/j.bmcl.2019.03.021 30952590
     [Google Scholar]
  37. MancusoR. CugliettaS. StrangisR. GabrieleB. Synthesis of benzothiophene-3-carboxylic esters by palladium iodide-catalyzed oxidative cyclization-deprotection-alkoxycarbonylation sequence under aerobic conditions.J. Org. Chem.20238885180518610.1021/acs.joc.2c00686 35537181
     [Google Scholar]
  38. NageshH.K. PadmashaliB. SandeepC. YuvarajT.C.M. SiddeshM.B. MallikarjunaS.M. Synthesis and antimicrobial activity of benzothiophene substituted coumarins, pyrimidines and pyrazole as new scaffold.Int. J. Pharm. Sci. Rev. Res.201428610
     [Google Scholar]
  39. PenthalaN.R. SonarV.N. HornJ. LeggasM. YadlapalliJ.S.K.B. CrooksP.A. Synthesis and evaluation of a series of benzothiophene acrylonitrile analogs as anticancer agents.MedChem-Comm2013471073107810.1039/c3md00130j 23956835
     [Google Scholar]
  40. JagtapV.A. AgasimundinY.S. Synthesis and preliminary evaluation of some 2-amino-n′-[substituted]-4, 5, 6, 7-tetrahydro-1-benzothiophene-3-carbohydrazide as antimicrobial agents.J. Pharm. Res.201591014
     [Google Scholar]
  41. DengQ. YuA. ZhouJ. CaoQ. MengX. construction of benzothiophene or benzothiopheno[2,3- e]azepinedione derivatives via three-component domino or one-pot sequences.J. Org. Chem.20208519122701228310.1021/acs.joc.0c01505 32883080
     [Google Scholar]
  42. HuangJ. Organic transformation of benzothiophenes by c−s bond cleavage beyond reductive desulfurization.Eur. J. Org. Chem.20212021425775578710.1002/ejoc.202100989
     [Google Scholar]
  43. RaoG.K. Novel schiff bases of 4-hydroxy 6-carboxhydrazino benzofuran analogs: Synthesis and pharmacological study.J. Pharmacol. Toxicol20072548148810.3923/jpt.2007.481.488
     [Google Scholar]
  44. IsloorA.M. KallurayaB. Sridhar PaiK. Synthesis, characterization and biological activities of some new benzo[b]thiophene derivatives.Eur. J. Med. Chem.201045282583010.1016/j.ejmech.2009.11.015 19945198
     [Google Scholar]
  45. GuglielmiP. SecciD. PetzerA. BagettaD. ChimentiP. RotondiG. FerranteC. RecinellaL. LeoneS. AlcaroS. ZenginG. PetzerJ.P. OrtusoF. CarradoriS. Benzo[ b]tiophen-3-ol derivatives as effective inhibitors of human monoamine oxidase: Design, synthesis, and biological activity.J. Enzyme Inhib. Med. Chem.20193411511152510.1080/14756366.2019.1653864 31422706
     [Google Scholar]
  46. XueS. GuoH. LiuM. JinJ. JuD. LiuZ. LiZ. Synthesis of a novel class of substituted benzothiophene or benzofuran derivatives as BMP-2 up-regulators and evaluation of the BMP-2-up-regulating effects in vitro and the effects on glucocorticoid-induced osteoporosis in rats.Eur. J. Med. Chem.20159615116110.1016/j.ejmech.2015.04.016 25874339
     [Google Scholar]
  47. WangS. BeckR. BlenchT. BurdA. BuxtonS. MalicM. AyeleT. ShaikhS. ChahwalaS. ChanderC. HollandR. MeretteS. ZhaoL. BlackneyM. WattsA. Studies of benzothiophene template as potent factor IXa (FIXa) inhibitors in thrombosis.J. Med. Chem.20105341465147210.1021/jm901475e 20121198
     [Google Scholar]
  48. LiW.Z. XiH.Z. WangY.J. MaH.B. ChengZ.Q. YangY. WuM.L. LiuT.M. YangW. WangQ. LiaoM.Y. XiaY. ZhangY.W. Design, synthesis, and biological evaluation of benzo[b]thiophene1,1‐dioxide derivatives as potent STAT3 inhibitors.Chem. Biol. Drug Des.202198583584910.1111/cbdd.13939 34416096
     [Google Scholar]
  49. XieH.X. ZhangJ. LiY. ZhangJ.H. LiuS.K. ZhangJ. ZhengH. HaoG.Z. ZhuK.K. JiangC.S. Novel tetrahydrobenzo[b]thiophen-2-yl)urea derivatives as novel α-glucosidase inhibitors: Synthesis, kinetics study, molecular docking, and in vivo anti-hyperglycemic evaluation.Bioorg. Chem.202111510523610.1016/j.bioorg.2021.105236 34411978
     [Google Scholar]
  50. QueirozM.J.R.P. FerreiraI.C.F.R. GaetanoY.D. KirschG. CalhelhaR.C. EstevinhoL.M. Synthesis and antimicrobial activity studies of ortho-chlorodiarylamines and heteroaromatic tetracyclic systems in the benzo[b]thiophene series.Bioorg. Med. Chem.200614206827683110.1016/j.bmc.2006.06.035 16843669
     [Google Scholar]
  51. ElHadyA.K. El-GamilD.S. ChenP.J. HwangT.L. AbadiA.H. Abdel-HalimM. EngelM. 5-Methoxybenzothiophene-2-carboxamides as inhibitors of Clk1/4: Optimization of selectivity and cellular potency.Molecules2021264100110.3390/molecules26041001 33668683
     [Google Scholar]
  52. LiuH. BoltonJ.L. ThatcherG.R.J. Chemical modification modulates estrogenic activity, oxidative reactivity, and metabolic stability in 4'F-DMA, a new benzothiophene selective estrogen receptor modulator.Chem. Res. Toxicol.200619677978710.1021/tx050326r 16780356
     [Google Scholar]
  53. Romero-ParraJ. Mella-RaipánJ. PalmieriV. AllaràM. TorresM.J. Pessoa-MahanaH. Iturriaga-VásquezP. EscobarR. FaúndezM. Di MarzoV. Pessoa-MahanaC.D. Synthesis, binding assays, cytotoxic activity and docking studies of benzimidazole and benzothiophene derivatives with selective affinity for the CB2 cannabinoid receptor.Eur. J. Med. Chem.2016124173510.1016/j.ejmech.2016.08.005 27560280
     [Google Scholar]
  54. DömötörO. TeixeiraR.G. SpenglerG. AvecillaF. MarquesF. Lenis-RojasO.A. MatosC.P. de AlmeidaR.F.M. EnyedyÉ.A. TomazA.I. Ruthenium(II) polypyridyl complexes with benzothiophene and benzimidazole derivatives: Synthesis, antitumor activity, solution studies and biospeciation.J. Inorg. Biochem.202323811205810.1016/j.jinorgbio.2022.112058 36375357
     [Google Scholar]
  55. EldehnaW.M. Al-AnsaryG.H. Al-WarhiT. JaballahM.Y. ElaasserM. RashedM. Identification of novel ureido benzothiophenes as dual VEGFR-2/EGFR anticancer agents.Bioorg. Chem.202414310703710.1016/j.bioorg.2023.107037 38134521
     [Google Scholar]
  56. PintoE. QueirozM.J.R.P. Vale-SilvaL.A. OliveiraJ.F. BegouinA. BegouinJ.M. KirschG. Antifungal activity of synthetic di(hetero)arylamines based on the benzo[b]thiophene moiety.Bioorg. Med. Chem.200816178172817710.1016/j.bmc.2008.07.042 18678498
     [Google Scholar]
  57. TuS. XieY.Q. GuiS.Z. YeL.Y. HuangZ.L. HuangY.B. CheL.M. Synthesis and fungicidal activities of novel benzothiophene-substituted oxime ether strobilurins.Bioorg. Med. Chem. Lett.20142492173217610.1016/j.bmcl.2014.03.024 24717155
     [Google Scholar]
  58. El-MiligyM.M.M. HazzaaA.A. El-MessmaryH. NassraR.A. El-HawashS.A.M. New hybrid molecules combining benzothiophene or benzofuran with rhodanine as dual COX-1/2 and 5-LOX inhibitors: Synthesis, biological evaluation and docking study.Bioorg. Chem.20177210211510.1016/j.bioorg.2017.03.012 28390993
     [Google Scholar]
  59. BorsariC. Jiménez-AntónM.D. EickJ. BifeldE. TorradoJ.J. Olías-MoleroA.I. CorralM.J. SantaremN. BaptistaC. SeveriL. GulS. WolfM. KuzikovM. EllingerB. ReinshagenJ. WittG. LincianoP. TaitA. CostantinoL. LucianiR. Tejera NevadoP. Zander-DinseD. FrancoC.H. FerrariS. MoraesC.B. Cordeiro-da-SilvaA. PonteriniG. ClosJ. AlundaJ.M. CostiM.P. Discovery of a benzothiophene-flavonol halting miltefosine and antimonial drug resistance in Leishmania parasites through the application of medicinal chemistry, screening and genomics.Eur. J. Med. Chem.201918311167610.1016/j.ejmech.2019.111676 31542713
     [Google Scholar]
  60. ÜnverY. ÜnlüerD. DırekelŞ. DurdağiS. Bis benzothiophene Schiff bases: Synthesis and in silico-guided biological activity studies.Turk. J. Chem.20204441164117610.3906/kim‑2004‑78 33488220
     [Google Scholar]
  61. PieroniM. AzzaliE. BasilicoN. ParapiniS. ZolkiewskiM. BeatoC. AnnunziatoG. BrunoA. VacondioF. CostantinoG. Accepting the invitation to open innovation in malaria drug discovery: Synthesis, biological evaluation, and investigation on the structure-activity relationships of benzo[ b]thiophene-2-carboxamides as antimalarial agents.J. Med. Chem.20176051959197010.1021/acs.jmedchem.6b01685 28128956
     [Google Scholar]
  62. ChandrasekeraN.S. BaileyM.A. FilesM. AllingT. FlorioS.K. OllingerJ. OdingoJ.O. ParishT. Synthesis and anti-tubercular activity of 3-substituted benzo[b]thiophene-1,1-dioxides.PeerJ20142e61210.7717/peerj.612 25320680
     [Google Scholar]
  63. De NanteuilG. Lila-AmbroiseC. RupinA. VallezM.O. VerbeurenT.J. New fibrinolytic agents: Benzothiophene derivatives as inhibitors of the t-PA-PAI-1 complex formation.Bioorg. Med. Chem. Lett.200313101705170810.1016/S0960‑894X(03)00233‑6 12729646
     [Google Scholar]
  64. GuoH. ShaoH. YangZ. XueS. LiX. LiuZ. HeX. JiangJ. ZhangY. SiS. LiZ. Substituted benzothiophene or benzofuran derivatives as a novel class of bone morphogenetic protein-2 up-regulators: Synthesis, structure-activity relationships, and preventive bone loss efficacies in senescence accelerated mice (SAMP6) and ovariectomized rats.J. Med. Chem.20105341819182910.1021/jm901685n 20088515
     [Google Scholar]
  65. ChiummientoL. FunicelloM. LupattelliP. TramutolaF. BertiF. Marino-MerloF. Synthesis and biological evaluation of novel small non-peptidic HIV-1 PIs: The benzothiophene ring as an effective moiety.Bioorg. Med. Chem. Lett.20122282948295010.1016/j.bmcl.2012.02.046 22414613
     [Google Scholar]
  66. HaoM. LiY. ZhangS.W. YangW. Investigation on the binding mode of benzothiophene analogues as potent factor IXa (FIXa) inhibitors in thrombosis by CoMFA, docking and molecular dynamic studies.J. Enzyme Inhib. Med. Chem.201126679280410.3109/14756366.2011.554414 21381886
     [Google Scholar]
  67. HurW. RosenH. GrayN.S. A benzo[ b]thiophene-based selective type 4 S1P receptor agonist.Bioorg. Med. Chem. Lett.20172711510.1016/j.bmcl.2016.11.050 27894870
     [Google Scholar]
  68. ChouY.L. DaveyD.D. EagenK.A. GriedelB.D. KaranjawalaR. PhillipsG.B. SacchiK.L. ShawK.J. WuS.C. LentzD. LiangA.M. TrinhL. MorrisseyM.M. KochannyM.J. Structure-Activity relationships of substituted benzothiophene-anthranilamide factor Xa inhibitors.Bioorg. Med. Chem. Lett.200313350751110.1016/S0960‑894X(02)00938‑1 12565961
     [Google Scholar]
/content/journals/mc/10.2174/0115734064315107240603055845
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An Overview of the Pharmacological Activities and Synthesis of Benzothiophene Derivatives
Medicinal Chemistry 20, 839 (2024); https://doi.org/10.2174/0115734064315107240603055845
/content/journals/mc/10.2174/0115734064315107240603055845
/content/journals/mc/10.2174/0115734064315107240603055845
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  • Article Type:     Review Article
Keyword(s): aromatic compounds; Benzothiophene; biological activities; derivatives; heterocyclic compounds; organic compounds

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