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Volume 20, Issue 9
  • ISSN: 1573-4064
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Abstract

Introduction

Drug resistance to existing antimicrobial drugs has become a serious threat to human health, which highlights the need to develop new antimicrobial agents.

Methods

In this study, a new set of 3-hydroxypyridine-4-one derivatives () was synthesized, and the antimicrobial effects of these derivatives were evaluated against a variety of microorganisms using the microdilution method. The antimicrobial evaluation indicated that compound , with an electron-donating group -OCH at the meta position of the phenyl ring, was the most active compound against and species with an MIC value of 32 µg/mL. Compound was more potent than ampicillin as a reference drug.

Results

The antifungal results showed that the studied derivatives had moderate effects (MIC = 128-512 µg/mL) against . and species. The molecular modeling studies revealed the possible mechanism and suitable interactions of these derivatives with the target protein.

Conclusion

The obtained biological results offer valuable insights into the design of more effective antimicrobial agents.

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2024-06-04
2024-11-14

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New 3-Hydroxypyridine-4-one Analogues: Their Synthesis, Antimicrobial Evaluation, Molecular Docking, and In Silico ADME Prediction
Medicinal Chemistry 20, 900 (2024); https://doi.org/10.2174/0115734064307744240523112710
/content/journals/mc/10.2174/0115734064307744240523112710
/content/journals/mc/10.2174/0115734064307744240523112710
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  • Article Type:     Research Article
Keyword(s): 3-hydroxypyridine-4-one; ADME prediction; antibacterial; antifungal; molecular docking study; Synthesis

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