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Volume 20, Issue 10
  • ISSN: 1573-4064
  • E-ISSN: 1875-6638

Abstract

Background

Fungal infections have posed a big challenge in the management of their treatment. Due to the resistance and toxicity of existing drug molecules in the light of pandemic infections, like COVID-19, there is an urgent need to find newer derivatives of active molecules, which can be effective in fungal infections.

Objective

In the present study, we aimed to design pyrazole derivatives using molecular modeling studies against target 1EA1 and synthesize 10 molecules of pyrazole derivatives using a multi-step synthesis approach.

Methods

Designed pyrazole derivatives were synthesized by conventional organic methods. The newly synthesized pyrazole molecules were characterized by using FT-IR, 1HNMR, 13CNMR, and LC-MS techniques. Molecular docking studies were also performed. The antifungal activity of newly synthesized compounds was assessed against and using the well plate method.

Results

Two of the compounds, OK-7 and OK-8, have been found to show significant docking interaction with target protein 1EA1. These two compounds have also been found to show significant anti-fungal activity against and when compared to the standard fluconazole. The Minimum Inhibitory Concentration (MIC) value of these two compounds has been found to be 50 µg/ml.

Conclusion

Pyrazole derivatives with -CH, CHO-, and -CN groups have been found to be active against tested fungi and can be further explored for their potential as promising anti-fungal agents for applications in the field of medicinal chemistry.

© 2024 Bentham Science Publishers
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2025-05-20

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Design, Synthesis and Evaluation of Antifungal Activity of Pyrazoleacetamide Derivatives
Med. Chem. 20, 957 (2024); https://doi.org/10.2174/0115734064300961240417063246
/content/journals/mc/10.2174/0115734064300961240417063246
/content/journals/mc/10.2174/0115734064300961240417063246
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  • Article Type:     Research Article
Keyword(s): 1EA1; anti-fungal; Aspergillus niger; Candida albicans; flow chemistry; Pyrazole

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