Letters in Organic Chemistry - Volume 22, Issue 1, 2025

In this study, we have developed an expeditious and efficient method for the synthesis of 2,4,5–triaryl imidazole derivatives using thiamine hydrochloride as a catalyst. The one-pot, solvent-free-multicomponent reaction of an aromatic/heterocyclic aldehyde with benzyl and ammonium acetate at reflux conditions leads to the formation of title compounds in extremely good yields. This protocol offers several features, suc Read More

Many natural and synthetic steroidal compounds have been converted by biotransformation to get highly valuable products for pharmaceuticals or chemical intermediates for the production of drugs. This review summarizes the biotransformation of sixty-six steroids 1-66 (ten of pregnane 1-10, fifty of androstane 11-60 while six steroids of estrane series 61-66) by using different strains of Rhizopus arrhizus, a well-known fungus o Read More

Oxadiazole is an organic compound featuring a heterocyclic ring housing carbon, oxygen, and nitrogen atoms. Due to their heightened stability in biological environments, oxadiazole rings exhibit significant biological activities, effectively addressing health challenges like infectious diseases and chronic conditions in medicinal chemistry. The main objective of this review is to discuss various synthetic approaches related to 1,3,4-o Read More

Cancer is a global health issue, and cancer cells' resistance to existing treatments has prompted a search for new anticancer drugs. The DNA of cancer cells is regarded as the primary target for developing new molecules. In-silico studies aid in the optimization of current pharmacophores and the development of new molecules. This study aimed to optimize the pharmacophore utilizing QSAR studies and pharmacophore m Read More

4-Hydroxyquinoline-2(1H)-ones exhibit multiple biological activities, and studying their synthetic methods is of great significance. In the presence of tetramethylguanidine and silver nitrate, 4-hydroxyquinoline-2(1H)-ones were efficiently synthesized from 2-ethynylanilines and carbon dioxide under atmospheric pressure. The reaction conditions, such as types of silver catalysts and reaction solvents, were optimized, and the ap Read More

β-(N-arylamino)acrylates are building blocks of great industrial interest as they allow the obtention of a variety of heterocyclic substances, such as quinoline and pyridone derivatives. Therefore, the development of new methodologies for the synthesis of these substances is still of interest. In this work, fourteen β-(N-arylamino)acrylates were synthesized in a multigram scale from the reaction of mono- and di-substituted anilin Read More

The synthesis of α,β-unsaturated compounds is crucial in organic chemistry, especially in drug discovery and pharmaceutical development. In this study, NCP@POCl2-x (Fe3O4@SiO2@chitosan@POCl2-x) has been introduced as a new, environmentally friendly, and highly efficient heterogeneous magnetic nanocatalyst for the synthesis of α,β-unsaturated carboxylic acids. This catalyst facilitates the in situ transformation of POCl2- Read More

An organocatalytic, one-pot four-center two-component coupling reaction has been developed for the synthesis of tetrahydro-1H,7H-chromeno[3,4-c]chromen-1-one derivatives. The reaction proceeds smoothly in the presence of 5 mol% DL-Proline in methanol under reflux conditions. This method involves the Knoevenagel condensation of O-alkynyl tethered 2-hydroxybenzaldehydes with cyclic 1,3-diketones Read More