Utilizing NCP@PO(OH)2 as a Core-Shell Magnetic Nano-Catalyst for the Conversion of β-Hydroxy Nitrile to α,β-Unsaturated Carboxylic Acid

Farzaneh Ebrahimzadeh

doi:10.2174/0115701786307956240522081438

ISSN: 1570-1786
E-ISSN: 1875-6255

Utilizing NCP@PO(OH)2 as a Core-Shell Magnetic Nano-Catalyst for the Conversion of β-Hydroxy Nitrile to α,β-Unsaturated Carboxylic Acid
By Farzaneh Ebrahimzadeh¹
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¹ Department of Chemistry, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran
Source: Letters in Organic Chemistry, Volume 22, Issue 1, Jan 2025, p. 70 - 77
DOI: https://doi.org/10.2174/0115701786307956240522081438
- Received: 24 Feb 2024
- Accepted: 25 Mar 2024
- Available online: 29 May 2024

Abstract

The synthesis of α,β-unsaturated compounds is crucial in organic chemistry, especially in drug discovery and pharmaceutical development. In this study, NCP@POCl2-x (Fe3O4@SiO2@chitosan@POCl2-x) has been introduced as a new, environmentally friendly, and highly efficient heterogeneous magnetic nanocatalyst for the synthesis of α,β-unsaturated carboxylic acids. This catalyst facilitates the in situ transformation of POCl2-x to PO(OH)2 in the presence of water, effectively converting β-hydroxy nitriles into α,β-unsaturated carboxylic acids through a specific mechanism involving water and heat. The reactions display notable regioselectivity, leading to high-purity products and quantitative yields. NCP@PO(OH)2 exhibits heterogeneity, magnetic properties, straightforward recovery, and outstanding performance, making it a valuable catalyst for efficient and selective transformations of β-hydroxy nitriles. Additionally, it can be easily separated from the mixture of reactions using external magnetic forces.

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2025-07-09

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/content/journals/loc/10.2174/0115701786307956240522081438

Utilizing NCP@PO(OH)2 as a Core-Shell Magnetic Nano-Catalyst for the Conversion of β-Hydroxy Nitrile to α,β-Unsaturated Carboxylic Acid

Lett. Org. Chem. 22, 70 (2025); https://doi.org/10.2174/0115701786307956240522081438

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The ¹H NMR, ¹³C NMR data, and FTIR spectra of the products have been included in the supporting information. These supplementary materials provide additional details and characterization of the products for reference.

Article Type: Research Article

Keyword(s): Core-shell; heterogeneous catalysis; magnetic nanocomposite; modified chitosan; nanocatalyst; regioselective synthesis; α,β-unsaturated carboxylic acid; β-hydroxy nitrile

Utilizing NCP@PO(OH)2 as a Core-Shell Magnetic Nano-Catalyst for the Conversion of β-Hydroxy Nitrile to α,β-Unsaturated Carboxylic Acid

Abstract

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The ¹H NMR, ¹³C NMR data, and FTIR spectra of the products have been included in the supporting information. These supplementary materials provide additional details and characterization of the products for reference.

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Utilizing NCP@PO(OH)2 as a Core-Shell Magnetic Nano-Catalyst for the Conversion of β-Hydroxy Nitrile to α,β-Unsaturated Carboxylic Acid

Abstract

The 1H NMR, 13C NMR data, and FTIR spectra of the products have been included in the supporting information. These supplementary materials provide additional details and characterization of the products for reference.

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The ¹H NMR, ¹³C NMR data, and FTIR spectra of the products have been included in the supporting information. These supplementary materials provide additional details and characterization of the products for reference.