Synthesis of 4-hydroxyquinoline-2(1H)-ones Based on Ag(I)-catalyzed Carbon Dioxide Fixation on 2-alknylanilines

Xin-Yu Lin; Guo-Jun Chen; Su-Zhe Wu; Ke-Xuan Xu; Xiao-Tian Zhang; Qi Feng

doi:10.2174/0115701786302455240603070018

ISSN: 1570-1786
E-ISSN: 1875-6255

Synthesis of 4-hydroxyquinoline-2(1H)-ones Based on Ag(I)-catalyzed Carbon Dioxide Fixation on 2-alknylanilines
Authors: Xin-Yu Lin¹, Guo-Jun Chen¹, Su-Zhe Wu¹, Ke-Xuan Xu¹, Xiao-Tian Zhang¹ and Qi Feng¹
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¹ Department of Science Education, School of Education, Zhejiang International Studies University, Hangzhou, China
Source: Letters in Organic Chemistry, Volume 22, Issue 1, Jan 2025, p. 56 - 60
DOI: https://doi.org/10.2174/0115701786302455240603070018
- Received: 15 Feb 2024
- Accepted: 04 Apr 2024
- Available online: 21 Jun 2024

Abstract

4-Hydroxyquinoline-2(1H)-ones exhibit multiple biological activities, and studying their synthetic methods is of great significance. In the presence of tetramethylguanidine and silver nitrate, 4-hydroxyquinoline-2(1H)-ones were efficiently synthesized from 2-ethynylanilines and carbon dioxide under atmospheric pressure. The reaction conditions, such as types of silver catalysts and reaction solvents, were optimized, and the applicability of the substrate was preliminarily investigated. This method provides an alternative pathway for the synthesis of 4-hydroxyquinoline-2(1H)-ones and the conversion and utilization of carbon dioxide.

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2025-07-10

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/content/journals/loc/10.2174/0115701786302455240603070018

Synthesis of 4-hydroxyquinoline-2(1H)-ones Based on Ag(I)-catalyzed Carbon Dioxide Fixation on 2-alknylanilines

Lett. Org. Chem. 22, 56 (2025); https://doi.org/10.2174/0115701786302455240603070018

/content/journals/loc/10.2174/0115701786302455240603070018

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Copies of ¹H and ¹³C NMR spectra of compounds 2a-k and HRMS data for compounds 2f, 2h, and 2i are given on the publisher’s website along with the published article.

Article Type: Research Article

Keyword(s): 2-ethynylanilines; 4-Hydroxyquinoline-2(1H)–ones; atmospheric pressure; carbon dioxide; silver-catalyzed; tetramethylguanidine

Synthesis of 4-hydroxyquinoline-2(1H)-ones Based on Ag(I)-catalyzed Carbon Dioxide Fixation on 2-alknylanilines

Abstract

From This Site

Copies of ¹H and ¹³C NMR spectra of compounds 2a-k and HRMS data for compounds 2f, 2h, and 2i are given on the publisher’s website along with the published article.

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Synthesis of 4-hydroxyquinoline-2(1H)-ones Based on Ag(I)-catalyzed Carbon Dioxide Fixation on 2-alknylanilines

Abstract

Copies of 1H and 13C NMR spectra of compounds 2a-k and HRMS data for compounds 2f, 2h, and 2i are given on the publisher’s website along with the published article.

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Copies of ¹H and ¹³C NMR spectra of compounds 2a-k and HRMS data for compounds 2f, 2h, and 2i are given on the publisher’s website along with the published article.