Letters in Organic Chemistry - Volume 19, Issue 7, 2022

An efficient and green protocol has been introduced for the synthesis of benzimidazole derivatives using a pyruvic acid catalyst in the presence of water. Pyruvic acid catalyses the reaction of aromatic aldehydes with o-phenylenediamine efficiently, and products were obtained in good to excellent yields under sonication (50 °C) or under conventional heating (50 °C). The advantages of this synthetic methodology are the us Read More

Construction of the C-C bond has been a challenge for organic chemists because of the reactivity of carbon atoms. The development of nucleophilic carbon was started with the Grignard reagent, enolate, and then ylide, however, the aromatic carbon activation was challenging till the era of organometallic chemistry. The organometallic chemistry was recognized when the Nobel Prize 2010 was given for the C-C bond f Read More

This study describes the synthesis of the pyrido[1,2-a]azepine alkaloids. The bicyclic compound 1 containing the A-B core ring structure was synthesized in 17 steps in 1.7% overall yield starting from 4-pentyn-1-ol. The key steps involve an oxidation of 1,4 diol to lactone and an ene-yne ring closing metathesis reaction.

A highly efficient heterogeneous nanocatalyst based on modified poly (styrene-altmaleic anhydride) (MPSAMA) in three steps was fabricated. Then, the MPSAMA surface was modified using chlorosulfonic acid (CAS) to achieve a sulfonated MPSAMA (SMPSAMA) with high acidity and efficiency. FT-IR spectroscopy, CHNS analysis, FESEM, and TGA were employed to characterize the prepared nanocatalyst. The catalytic activity of the Read More

In this study, two novel hybrid series of artemisinin and quinazolinones were synthesized and evaluated in vitro cytotoxicity against two human cancer cell lines, including SKLu-1 (lung cancer), MCF- 7 (breast cancer). The bio-assay results indicated that most of the target compounds exhibited cytotoxic activities against both human cancer cell lines tested and seemed to be more cytotoxic toward the breast (MCF-7) ca Read More

Bifunctional ionic liquid [BIL] was found to be a highly effective catalyst for ether synthesis without any inorganic base or solvent. Using this protocol, different aryl substitutions were reacted with different phenols in good to excellent yields. The BIL is reusable without any loss in catalytic activity for nine consecutive cycles. The Williamson reaction is a convenient renovation in fine chemical synthesis since the ethers are i Read More

NiO nanoparticles are utilized to effectively strengthen annulated pyrano [2,3-d] pyrimidine synthesis through primary Knoevenagel, following Micheal and ultimate heterocyclization reactions of aldehyde, malononitrile, and barbituric acid. The characteristics of NiO nanoparticles are identified using advanced techniques, such as IR, UV, EDX, XRD, SEM, and TEM. The nano-NiO particles are mostly below < 100 nm in siz Read More

The adsorption of the Lenalidomide (LNA) drug on the surface of the B12N12 nanocluster has been studied using DFT and TD-DFT calculations. The quantum calculations have been performed at the B3LYP/6-311+G** level of theory in the solvent water. The change of DM also displays a charge transfer between LNA and nanocluster. The adsorption of the LNA drug from the O1 atom on the B12N12 nanocluster leads to higher el Read More