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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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Studies Towards the Synthesis of the Pyrido[1,2-a]azepine Alkaloids
- Source: Letters in Organic Chemistry, Volume 19, Issue 7, Jul 2022, p. 532 - 541
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- 01 Jul 2022
Abstract
This study describes the synthesis of the pyrido[1,2-a]azepine alkaloids. The bicyclic compound 1 containing the A-B core ring structure was synthesized in 17 steps in 1.7% overall yield starting from 4-pentyn-1-ol. The key steps involve an oxidation of 1,4 diol to lactone and an ene-yne ring closing metathesis reaction.
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