Letters in Organic Chemistry - Volume 16, Issue 5, 2019

The structural diversity of spiro heterocycles has achieved an extensive attention of organic chemists due to their vast synthetic applications. Among these, spiropyrazolines are gaining considerable prominence due to their biological and pharmacological activities, electrophotographic photosensitivity as well as their application as beneficial synthons for spirocyclopropanes, cyclobutanes, pyrrolidinones, pyrazoles, 3-ami Read More

The mechanism of addition of nucleophiles to the π-acid complexed alkynes has been studied successfully by the assessment of energy of intermediates and activation parameters. To elucidate the origin of stereoselectivity and predict the reaction pathways, the geometry optimizations of reactants, products, intermediates and transition states, were calculated by using density functional theory (DFT) at the B3LYP/6-31+ Read More

We developed a series of new hydrotalcite functionalized Ru catalytic system to synthesize formic acid via CO2 hydrogenation reaction. Advance analytical procedures like FTIR, N2 physisorption, ICP-OES, XPS, and TEM analysis were applied to understand the physiochemical nature of functionalized hydrotalcite materials. This well-analyzed system was used as catalysts for CO2 hydrogenation reaction (with and without Read More

Scale-up fermentation of the endophytic fungus Penicillium chrysogenum in biomaltpeptone media followed by cytotoxicity-guided fractionation led to the isolation of haenamindole, an unusual diketopiperazine (DKP) alkaloid, along with other five known DKPs. Haenamindole was elucidated on the basis of comprehensive 1D and 2D NMR spectroscopic including 15N-HSQC and 15NHMBC and mass spectrometric analyses. The co Read More

5-bromo-2-(prop-2-yn-1-yloxy)benzaldehyde (compound 3) and 3,5-di-tert-butyl-2-(prop-2- yn-1-yloxy)benzaldehyde (compound 5) were synthesized via nucleophilic substitution reactions. Compound 5 showed higher antioxidant capacity with respect to compound 3 in all the four different antioxidant activity methods used. Moreover, in phosphomolybdenum assay, compound 5, with 1.1 proportion value, showed al Read More

Pyrazine, a kojic acid having hydroxypyrone, and hydroquinone are the head compounds of different categories possessing a broad range of biological activities including anticancer and antioxidant activities, thus are interested in evaluating the cytotoxicity on K562 human leukemia cells and radical scavenging activities of these compounds in bonding together as ester compounds. Four hydroxypyrone containing-2-pyrazi Read More

A series of biologically active 3-quinoline carboxylic acid hydrazide-hydrazones has been synthesized from 3-quinoline carboxylic acid hydrazide and a variety of aldehydes, with moderate to good yields. The chemical structures of the new products were confirmed by elemental analysis, IR, and 1H NMR, 13C NMR spectral data. The structural and frontier molecular orbital (FMO) properties and the density functional theory (DFT) c Read More

One of the major challenges facing modern biochemical and biomedical technologies are finding molecular tools for diagnosis and detection of genetic diseases. In this connection, several classes of oligonucleotides have been developed that can recognize and bind to DNA and RNA with high affinity and sequence selectivity and withstand enzymatic degradation by proteases and nucleases; however, few can traverse the Read More