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- Volume 10, Issue 3, 2013
Letters in Organic Chemistry - Volume 10, Issue 3, 2013
Volume 10, Issue 3, 2013
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The Synthesis of Enantiomers of 6-tert-Butyl-6-methylmorpholine-2,5- dione Using Wang Resin Supported Mukaiyama Reagent
Authors: Anna Jakubowska, Joanna Babiuch and Katarzyna KuligThe synthesis of enantiomers of 6-tert-butyl-6-methylmorpholine-2,5-dione (3) using Wang resin supported 2- chloro- or 2-bromo- pyridinium triflate is described. The applied methodology could be considered as an interesting alternative to “classical” one and enables the synthesis of 6-tert-butyl-6-methylmorpholine-2,5-dione with higher yields and the isolation of product (3) is significantly easier.
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A Cost-Effective Method to Prepare Pure Vildagliptin
Authors: Jun Peng, Yue Feng, Zhu Tao, Yingjie Chen and Xiangnan HuA cost-effective synthetic approach to prepare vildagliptin under gentle experimental conditions has been reported with good yield and high purity. It was initiated with L-proline via successful reaction with chloroacetyl chloride in THF (Tetrahydrofuran) to give the 1-(2-chloroacetyl)-pyrrolidine-2-carboxylic acid, which was then treated by TCT (2, 4, 6-trichloro-1, 3, 5-triazine) in DCM (dichloromethane), and converted into 1-(2-chlo Read More
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Sulfuric Acid-modified PEG-6000 (PEG-SO3H): An Efficient, Bio-degradable and Reusable Catalyst for Synthesis of α, α´ bis(arylidene) Cycloalkanones Under Solvent-free Conditions
Authors: Mohammad A. Nasseri and Mehri SalimiA green and efficient method for synthesis of α,α´ -bis (arylidene) cycloalkanones, starting from aromatic aldehydes in reaction with ketones using sulfonated polyethylene glycol 6000 (PEG-SO3H) as a stable, reusable and biodegradable catalyst under solvent-free conditions at 80 °C is described. The use of a nontoxic, inexpensive, easily available and recyclable catalyst makes this protocol practical, environmentally frie Read More
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La(NO3)3.6H2O Catalyzed One-pot Highly Diastereoselective Synthesis of Functionalized Piperidines
La(NO3)3.6H2O was used as an efficient catalyst for highly diastereoselective synthesis of functionalized piperidines by one-pot five-component reactions of anilines and aromatic aldehydes with acetoacetic esters. This strategy proceeds by way of the Knoevenagel reaction followed by inter-molecular aza-Diels-Alder reaction. The main features of the current method comprise mild reaction conditions, easy work-up, eco-frien Read More
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Ionic Liquid Mediated Synthesis of Novel tetrahydroimidazo [1,2- a]pyrimidine-6-carboxylate Derivatives
A novel route for the synthesis of tetrahydroimidazo [1,2-a] pyrimidine-6-carboxylate derivatives in presence of 1-ethyl-3-methyl imidazolium hydrogen sulphate ionic liquid at room temperature has been reported via Biginelli reaction. The process offer several advantages such as short reaction time, excellent yield of products, simple work up procedure etc. 1-ethyl-3-methyl imidazolium hydrogen sulphate ionic liquid is Read More
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Synthesis of Novel Fused Coumarine and naphtho[2,1-b]pyrano[3,2- e][1,2,4] triazolo[1,5-c]pyrimidine Derivatives
Authors: Abderrahim Ben Said, Anis Romdhane, Nicolas Elie, David Touboul and Hichem Ben JannetNew 14-(Aryl)-14H-naphto[2,1-b]pyrano[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine-2-acetonitriles have been prepared. The chemical behaviour of these compounds was studied towards Knoevenagel condensation with salicylaldelyde derivatives, thus, a series of 2-(coumarin-3’’-yl)-14(Aryl)-14H-naphto[2,1-b]pyrano[3,2-e][1,2,4]triazolo[1,5- c]pyrimidines was obtain-ed. Their structures were characterized with IR, ES-HR-MS, 1H N Read More
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L-Proline as Reusable and Organo Catalyst for the One-Pot Synthesis of Substituted 2-Amino-4H-Chromenes
Authors: Farahnaz Kargar Behbahani, Mehdi Ghorbani, Mahdieh Sadeghpour and Mohamad MirzaeiL-proline catalyzed one-pot three-component condensation reaction of aromatic aldehydes, malononitrile and naphthols proceeded in EtOH to afford corresponding 2-amino-4H-chromenes in high to excellent yields at reflux conditions. The protocol found to be fairly general and the catalyst was reused in subsequent reactions with consistent activity. Moreover, this method offers several advantages including high to excellent Read More
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A Novel Synthesis of 1,4,7,10-Tetraazacyclododecane by the Tandem Reaction of a Vinylsulfonium Salt
Authors: Rui Huang, Chunsong Xie, Lin Huang and Jinhua Liu1,4,7,10-Tetraazacyclododecane was synthesized through 4 steps by using easily available diphenylsulfonium triflate as a key annulation reagent. The reaction condition was very mild and the yield was high. After oxidation and hydrolysis, 1,4,7,10-Tetraazacyclododecane, which had been proven to be the pivotal precursor for a wide range of MRI contrast reagents, was produced in an overall yield of 31%.
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Application of Silica Gel-supported Polyphosphoric Acid (PPA/SiO2) as a Reusable Solid Acid Catalyst for One-Pot Multi-Component Synthesis of 3,4,5-substituted furan-2(5H)-ones
Authors: Razieh Doostmohammadi and Nourallah Hazeri3,4,5-substituted furan-2(5H)-ones were One-Pot Multi-Component synthesized by the reaction of aldehydes, amines and dialkyl acetylenedicarboxylates using silica gel-supported polyphosphoric acid (PPA/SiO2) at room temperature. This reaction provides a convenient and efficient synthetic method of furan-2(5H)-one derivatives, and also reusability of catalyst.
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Facile N-Nitrosation of Secondary Amines Using Poly(N,N'-dibromo-Nethylene- benzene-1,3-disulfonamide)and N,N,N',N'-tetrabromobenzene- 1,3-disulfonamide/NaNO2 Under Mild Conditions
Authors: Ramin Ghorbani-Vaghei, Lotfi Shiri and Arash Ghorbani-ChoghamaraniIn this research project, a combination of poly(N,N'-dibromo-N-ethylene-benzene-1,3-disulfonamide) [PBBS] and/or(N,N,N',N'-tetrabromobenzene-1,3-disulfonamide) [TBBDA] with sodium nitrite in the presence of wet SiO2 (50% w/w) was used as an efficient nitrosating agent for the conversion of secondary amines to their corresponding nitroso compounds. N-Nitrosation reaction has been performed in dichloromethane at room Read More
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A Very Simple, Highly Efficient and Catalyst-free Procedure for the NFormylation of Amines Using Triethyl orthoformate in Water Under Ultrasound-irradiation
Authors: Davood Habibi, Hesam Sahebekhtiari, Mahmoud Nasrollahzadeh and Ahmad TaghipourN-Formylation of amines has efficiently been carried out in excellent yields by treatment of amines with triethyl orthoformate in water under ultrasound irradiation. The process is remarkably simple and environmentally benign.
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Efficient Synthesis of Aromatic Nitriles via Cyanation of Aryl Bromides and K4[Fe(CN)6] Catalyzed by a Palladium(II) Complex
Authors: Mengping Guo, Junying Ge, Zhiyong Zhu and Xiaochun WuCyanation of aryl bromides and K4[Fe(CN)6] were carried out in the presence of catalytic amounts of {[(PhCH2O)2P(CH3)2CHNCH(CH3)2]2PdCl2} (PdCl2L2) in DMF and a variety of Aromatic nitriles were obtained in good yields under aerobic conditions.
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Zinc-Mediated Chain Extension Reaction of o-Phenolic-l,3-diketone to o- Phenolic-l,4-diketone
Authors: Hui-Fang Liu, Ling-Guo Meng, Xiao-Li Hao, Qiao- Lin, Jian-Fa Li and Song XueA simple methodology has been developed for the synthesis of o-phenolic-l,4-diketones from the o-phenolicl, 3-diketones. The reaction performed in the presence of organozinc reagents under mild conditions afforded the products l,4-diketones in moderate yields.
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Novel and Versatile Photosensitized Oxygenation Reaction of α-Cedrene
Authors: Weiping Wu, Feng An, Zhengsong Geng, Ronghua Zhang and Zhiqin JiangThree types of photosensitized oxygenations of α-cedrene (CED) were investigated, including: rose bengal( RB)-sensitized photooxygenation of α-cedrene in acetonitrile produced one major stereospecific product (cedr-8- exoen-9α-ol), in which the double bond migrated to an adjacent position, this result demonstrated the singlet oxygen process; 9,10-dicyanoanthrathene (DCA) sensitized photooxygenation led to the for Read More
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Synthesis and Antifungal Activity of Some Novel (E)-2, 3-Dihydro-3- [(phenylamino) methylene]-4H-1-benzothiopyran-4-ones
Authors: Liu Xiao-Ming, Yang Geng-Liang, Song Ya-Li, Liu Jie-Jie, Wang Yang and Zhang Dong- NuanA series of novel (E)-2,3-dihydro-3-[(phenylamino)methylene]-4H-1-benzothiopyran-4-ones has been synthesized by using 2,3-dihydro-4H-1-benzothiopyran-4-ones as the starting material. The structures of the new compounds are characterized by UV-vis, IR, HRMS, 1H NMR, and 13C NMR. 2D NMR spectroscopic studies revealed that at room temperature, these compounds rather exist in the keto-enamine than in the Read More
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Volumes & issues
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Volume 22 (2025)
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Volume 21 (2024)
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Volume 20 (2023)
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Volume 19 (2022)
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Volume 18 (2021)
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Volume 17 (2020)
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Volume 16 (2019)
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Volume 15 (2018)
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Volume 14 (2017)
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Volume 13 (2016)
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Volume 12 (2015)
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Volume 11 (2014)
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Volume 10 (2013)
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Volume 9 (2012)
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Volume 8 (2011)
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Volume 7 (2010)
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Volume 6 (2009)
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Volume 5 (2008)
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Volume 4 (2007)
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Volume 3 (2006)
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Volume 2 (2005)
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Volume 1 (2004)
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