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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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La(NO3)3.6H2O Catalyzed One-pot Highly Diastereoselective Synthesis of Functionalized Piperidines
- Source: Letters in Organic Chemistry, Volume 10, Issue 3, Mar 2013, p. 171 - 177
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- 01 Mar 2013
Abstract
La(NO3)3.6H2O was used as an efficient catalyst for highly diastereoselective synthesis of functionalized piperidines by one-pot five-component reactions of anilines and aromatic aldehydes with acetoacetic esters. This strategy proceeds by way of the Knoevenagel reaction followed by inter-molecular aza-Diels-Alder reaction. The main features of the current method comprise mild reaction conditions, easy work-up, eco-friendliness, high atom economy, short times and the products were isolated with high yields.
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