Intramolecular Azide Cycloaddition enroute to the New Pyrrolo[2,1-c][1,2,3] triazolo[1,5-a][1,4]benzodiazepine Skeleton

G. Broggini; I. D. Marchi; M. Martinelli; G. Paladino; A. Penoni

doi:10.2174/1570178043400956

ISSN: 1570-1786
E-ISSN: 1875-6255

Intramolecular Azide Cycloaddition enroute to the New Pyrrolo[2,1-c][1,2,3] triazolo[1,5-a][1,4]benzodiazepine Skeleton
Authors: G. Broggini¹, I. D. Marchi², M. Martinelli³, G. Paladino⁴ and A. Penoni⁵
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¹ Dipartimento di Scienze Chimiche e Ambientali, Università dell'Insubria, via Valleggio 11, 22100 Como, Italy ² Dipartimento di Scienze Chimiche e Ambientali, Università dell'Insubria, via Valleggio 11, 22100 Como, Italy ³ Dipartimento di Scienze Chimiche e Ambientali, Università dell'Insubria, via Valleggio 11, 22100 Como, Italy ⁴ Dipartimento di Scienze Chimiche e Ambientali, Università dell'Insubria, via Valleggio 11, 22100 Como, Italy ⁵ Dipartimento di Scienze Chimiche e Ambientali, Università dell'Insubria, via Valleggio 11, 22100 Como, Italy
Source: Letters in Organic Chemistry, Volume 1, Issue 3, Jul 2004, p. 221 - 223
DOI: https://doi.org/10.2174/1570178043400956
- Available online: 01 Jul 2004

Abstract

The unknown pyrrolo[2,1-c][1,2,3]triazolo[1,5-a][1,4]benzodiazepin-8-one ring system has been synthesised starting from the N-Boc-L-proline methyl ester. The totally diastereoselective intramolecular 1,3- dipolar cycloaddition of the azide 9 constitutes the key step of the synthetic sequence.

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2004-07-01

2025-06-24

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Article Type: Review Article

Keyword(s): 1,4-benzodiazepin-5-ones; azides; diastereoselective reactions; intramolecular cycloadditions; pyrrolo[2,1-c][1,4]benzodiazepin-5-ones

Intramolecular Azide Cycloaddition enroute to the New Pyrrolo[2,1-c][1,2,3] triazolo[1,5-a][1,4]benzodiazepine Skeleton

Abstract

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