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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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Synthesis of Alicyclic β-lactams via the Ugi Reaction on a Solid Support
- Source: Letters in Organic Chemistry, Volume 1, Issue 3, Jul 2004, p. 215 - 220
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- 01 Jul 2004
Abstract
Via the Ugi 4-centre 3-component reaction (U-4C-3CR), bicyclic cis-2-azetidinone derivatives were synthetised from cyclic β-amino acids on Super Acid Sensitive Resin (Sasrin). 2-, 3- or 4-Formylbenzoic acid was immobilised on the resin through its carboxy function. The U-4C-3CR was also carried out in solution, making use of scavenger resins for purification.
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