2000

Letters in Drug Design & Discovery - Volume 21, Issue 15, 2024

Volume 21, Issue 15

Volume 21, Issue 15, 2024

- In silico Exploration of the Therapeutic Potential of Alkaloids as Anti-infective Agents
  
  Authors: Nidhi Rani, Praveen Kumar, Aditya Walia and Randhir Singh
  
  https://doi.org/10.2174/0115701808276535231212071700
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  Background
  Alkaloids are important phytoconstituents obtained from various plant sources.
  Methods
  The main objective of the study was to evaluate the anti-infective potential of alkaloids against 14α-demethylase, transpeptidase, and omicron spike protein using molecular docking studies. The potential constituents were identified and an ADMET study was performed.
  Results
  The study concluded that reserpine and tubocurarine exhibited potential activity against the three tested enzymes with good ADMET profile.
  Conclusion
  Reserpine and tubocurarine can further be explored to attain new candidates as anti-infective agents.
  
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