Volume 21, Issue 14

Letters in Drug Design & Discovery - Volume 21, Issue 14, 2024

Volume 21, Issue 14, 2024

- Vinpocetine Exerts Neuroprotective Effects via Downregulating α-Syn in Rotenone-induced Cellular Models of Parkinson’s Disease
  
  Authors: Meng Ji, Ji-Hua Xu, He-Yin Mi, Peng Jiang and Yue Li
  
  https://doi.org/10.2174/0115701808274204231012111936
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  Objective Vinpocetine (Vinp), a derivative of alkaloid vincristine with anti-inflammatory and antioxidant effects, has been shown to have neuroprotective effects in Parkinson's disease (PD). Its role and mechanisms, however, are not fully understood. Therefore, the aim of this study was to investigate the effects and possible mechanisms of Vinp on PD cells. Methods SH-SY5Y cells were treated with Vinp and then with Read More
  
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Letters in Drug Design & Discovery - Volume 21, Issue 14, 2024

Volume 21, Issue 14, 2024

Vinpocetine Exerts Neuroprotective Effects via Downregulating α-Syn in Rotenone-induced Cellular Models of Parkinson’s Disease

Volumes & issues

Volume 21 (2024)

Volume 20 (2023)

Volume 19 (2022)

Volume 18 (2021)

Volume 17 (2020)

Volume 16 (2019)

Volume 15 (2018)

Volume 14 (2017)

Volume 13 (2016)

Volume 12 (2015)

Volume 11 (2014)

Volume 10 (2013)

Volume 9 (2012)

Volume 8 (2011)

Volume 7 (2010)

Volume 6 (2009)

Volume 5 (2008)

Volume 4 (2007)

Volume 3 (2006)

Volume 2 (2005)

Volume 1 (2004)

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Discovery, Structural Determination and Anticancer Activities of Lactucinlike Guaianolides

Thermodynamic Aspects of Cancer: Possible Role of Negative Entropy in Tumor Growth, its Relation to Kinetic and Genetic Resistance

Immunomodulatory Properties of Synthetic Imidazolone Derivatives

Design and Prediction of ADME/Tox Properties of Novel Magnolol Derivatives as Anticancer Agents for NSCLC Using 3D-QSAR, Molecular Docking, MOLCAD and MM-GBSA Studies

Redox Active Iron at the Center of Oxidative Stress in Alzheimer Disease

Identifying Protein Binding Sites and Optimal Ligands

Phenyldihydroxypyrimidines as HCV NS5B RNA Dependent RNA Polymerase Inhibitors. Part I: Amides and Ureas

Phenyldihydroxypyrimidines as HCV NS5B RNA Dependent RNA Polymerase Inhibitors. Part II: Sulfonamides

Selection of a Catalytically Active Enzyme In Vivo Via Phage Display of its Product

A Comprehensive Review of the Advancement in Omic Technologies in the Field of Drug Discovery and Development