Letters in Drug Design & Discovery - Volume 14, Issue 5, 2017

Background: The positional effects of the methoxy- and hydroxyl substituents in the phenyl ring were examined in vivo for distinct receptor classes in order to gain an insight into the mechanism by which isomeric compounds (2S,4R,4aR,8R,8aR)-2-(3(4)-hydroxy-4(3)-methoxyphenyl)-4,7-dimethyl- 3,4,4a,5,8, 8a-hexahydro-2H-chromene-4,8-diols 1 and 2 exhibit their pharmacological activity. Conclusion: Our findings sugge Read More

Background: There has been a growing interest of pharmacophore hybridization in anticancer drug discovery that may be utilized for designing new potential lead candidates against multiple targets that may exhibit synergetic activity. Pyrazole and 1,2,3-triazole nucleus are amongst the most important ones. Method: Statistically validated 3D-QSAR models of the pyrazolo-triazole hybrids on 4 different types of human can Read More

Background: Carbamate compounds have attracted a great deal of interest in medicinal chemistry due to their inhibition potential against cholinesterase enzymes. Method: Hence, this study was undertaken to synthesize new piperazine derivatives including dithiocarbamate moiety, which is the bioisoster of carbamate. Twenty eight 4-(dimethylaminoalkyl) piperazine-1-carbodithioate derivatives (3a-3n, 4a-4n) were sy Read More

Background: Glucokinase activators (GKAs) are the new class of candidate drugs which act on glucokinase (GK) enzyme and show their hypoglycaemic activity. Objective: The present work was planned to synthesize and evaluate the antidiabetic activity of a series of newer benzamide derivatives as potential GKAs. Method: This work involved synthesis of newer benzamide derivatives from benzoic acid and t Read More

Background: Cancer is one of the leading causes of morbidity and mortality worldwide and extensive efforts have been devoted to the discovery of new anticancer agents. In the last few decades, the clinical efficacy of tiazofurin and its analogues, dasatinib and bleomycins has pointed out the importance of thiazole moiety in the field of cancer treatment. Methods: In the present paper, some thiazolyl hydrazone derivatives wer Read More

Introduction: The demand for new antiviral agents is creating all possible approaches towards the development of newantiviral drugs. One of the possible methodologies that can be used for the discovery of such drugs is the screening of novel organophosphorus compounds for antiviral activity. Objectives: The primary objective of the study was to discover potential new anti-viral agents by phosphorylating ribosyl moiety Read More

Background: Mannich bases are an important compounds in medicinal chemistry. They have wide range of biological activities including carbonic anhydrase (CA) inhibitory and acetylcholine esterase inhibitory (AChE) activities. Objective: It was aimed to synthesize Mannich bases, 1-aryl-3-(morpholin-4-yl/piperidin-1-yl)-1- propanone hydrochloride, by microwave irradiation and conventional heating methods to compare the Read More

Background: Polo like kinase 2 (PLK2) has been reported as a new target for developing novel anticancer drugs. Here, three-dimensional quantitative structure-activity relationship (3D-QSAR), docking and molecular dynamics (MD) simulation studies were carried out on 70 pyridopyrimidine derivatives to focus on the structural necessities of potent PLK2 inhibitors. Method: An optimal CoMFA model with cross Read More

Background: Quinoline-containing compounds have displayed an impressive array of pharmacological actions over the years, including antiprotozoal activities. Methods: In this work we evaluate antimalarial and antileishmanial activities of some aminoquinoline (AMQ) derivatives hybridized to sulfa or isoniazid or hydrazine groups. Results and Conclusion: In murine model of infection occasioned by P. berghei, comp Read More

Background: Hydrogels, due to their unique potentials such as high-water content and hydrophilicity are interest for the controlled release of drug molecules. But most of hydrogels are not biodegradable. Method: To address these issues, we have developed hydrogels that combined sensitive polymers such as poly (acrylic acid) and polymethacrylic acid based on Starch and Chitosan. Owing to their unique potentials through co Read More

Background: A series of novel N-(substituted aryl/alkylcarbamothioyl)-4-[5-(4-methylphenyl)- 3-(trifluoromethyl)-1H-pyrazol-1-yl]benzene sulfonamides [SGK 318, 319, 320, 324, 327] and N-(3- substitutedaryl/alkyl-4-oxo-1,3-thiazolidin-2-ylidene)-4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1- yl]benzenesulfonamides[SGK 328, 329, 330, 334, 337] were synthesized and tested for their quorum sen Read More

Overexpression and aberrant activation of NF-ΚB has been extensively documented during the development and progression of head and neck squamous cell carcinoma (HNSCC), the sixth most common cancer worldwide. Accumulating evidence indicates that NF-ΚB plays a central role in HNSCC development via regulation of a multitude of genes involved in cell proliferation, cell survival, apoptosis evasion, inflammation, i Read More