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Volume 21, Issue 14
  • ISSN: 1570-1808
  • E-ISSN: 1875-628X

Abstract

Ursolic acid (UA) is a widely distributed triterpenoid in nature. Due to its easy availability and multiple pharmacological activities, ursolic acid has attracted much attention in the field of medicine and pharmacology. To overcome the disadvantages of bioavailability and poor water solubility during the ursolic acid application, we focused on the synthetic and medicinal properties of UA derivatives modified at C-3 and C-28 sites. This review presents the synthesis of UA derivatives with modification at C-3 and C-28 sites and their pharmacological activity, which may provide some important information for further research and development of UA-based drugs.

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2024-11-01
2024-11-19

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/content/journals/lddd/10.2174/1570180820666230823093545
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The Synthesis and Pharmacological Activity of Ursolic Acid Derivatives Modified at C-28 and C-3 Sites
Letters in Drug Design & Discovery 21, 2799 (2024); https://doi.org/10.2174/1570180820666230823093545
/content/journals/lddd/10.2174/1570180820666230823093545
/content/journals/lddd/10.2174/1570180820666230823093545
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  • Article Type:     Review Article
Keyword(s): Pharmacological activity; synthesis; triterpenes; triterpenoid compounds; ursolic acid derivatives

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