Full text loading...
- ISSN: 1570-1808
- E-ISSN: 1875-628X
-
Inherent Gene Expression Variabilities and the Need for Personalized Drug Dosage
- Source: Letters in Drug Design & Discovery, Volume 5, Issue 3, Apr 2008, p. 193 - 208
-
- 01 Apr 2008
Abstract
Simulations of the effects of DNA polymorphisms, transcriptional noise, and epigenetic differences within and among populations suggest highly divergent responses to drug dosage, resulting in considerable risk of adverse effects. These findings highlight the need for personalized calibration of drug dosage.
© Bentham Science Publishers