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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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Estrogen Receptor: Structural Differences and Potential Implications on Selectivity Examined by the GRID/CPCA Approach
- Source: Letters in Drug Design & Discovery, Volume 5, Issue 3, Apr 2008, p. 182 - 192
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- 01 Apr 2008
Abstract
Selective Estrogen Receptor Modulators (SERMs) have been developed, but the selectivity towards the subtypes (ERα or ERβ) is not well understood. Based on three-dimensional structural properties of ligand binding domains, a model that takes into account this aspect was developed via molecular interaction fields and consensus principal component analysis (GRID/CPCA).
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