Skip to content
2000
Volume 5, Issue 1
  • ISSN: 1570-1808
  • E-ISSN: 1875-628X

Abstract

1,4-dihydropyridines are the emerging class of antitubercular agents. In this protocol we present, the syntheses, characterization details for the conformation of structures, antitubercular and anticancer activity results for some novel 1,4-dihydropyridines. The comparative molecular field analysis (CoMFA) model for 1,4-dihydropyridines was derived. The 3D QSAR model demonstrated good ability to predict activity of studied compounds (r2 = 0.97, q2 = 0.81). Based on the CoMFA steric and electrostatic contour maps, structure activity relationships were established for antitubercular activity.

Loading

Article metrics loading...

/content/journals/lddd/10.2174/157018008783406688
2008-01-01
2025-06-12
Loading full text...

Full text loading...

/content/journals/lddd/10.2174/157018008783406688
Loading

  • Article Type:
    Research Article
Keyword(s): 1,4-Dihydropyridines; 3D-QSAR; Anticancer activity; Antitubercular activity; CoMFA
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test