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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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Design and Synthesis of a (N-Alkylaminoalkyl-Substituted)Arylalkenylamide Drug Discovery Library
- Source: Letters in Drug Design & Discovery, Volume 4, Issue 8, Dec 2007, p. 605 - 610
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- 01 Dec 2007
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Abstract
To discover new potential sigma ligands, a library of 64 members based on a carbamidic scaffold was designed and a synthetic protocol, based on PASPS and MAOS techniques, was developed and optimized. Applying the developed protocol the library compounds were obtained in high purity, suitable for biological screening.
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