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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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Design, Synthesis and Biological Activity of A-C8/C-C2-Linked 6-Chloropurine-Pyrrolobenzodiazepine Hybrids as Anticancer Agents
- Source: Letters in Drug Design & Discovery, Volume 4, Issue 8, Dec 2007, p. 596 - 604
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- 01 Dec 2007
Abstract
New A-C8 and C-C2-linked 6-chloropurine-pyrrolo[2,1-c][1,4]benzodiazepine hybrids have been prepared and evaluated for their anticancer potential. The molecular modeling studies might be explained in terms of effect of the molecule on binding in the minor groove of DNA and also comparison to both A-C8/C-C2-position of the PBD. These PBD conjugates have shown DNA-binding ability and promising anticancer activity.
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