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2000
Volume 4, Issue 2
  • ISSN: 1570-1808
  • E-ISSN: 1875-628X

Abstract

We rationally designed and synthesized a novel cationic polymer with intrinsic endosomolytic properties based on a semi-peptide monomer bridged by disulfide bonds. This polymer was shown to associate with DNA and to form polyplexes with gene transfection activity without addition of chloroquine, a known endosomolytic agent.

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/content/journals/lddd/10.2174/157018007779422569
2007-03-01
2025-05-28
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  • Article Type:
    Research Article
Keyword(s): Cationic polymer; Gene delivery; Transfection
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