Symmetrical Derivatives of C2-Substituted Pyrrolo[2,3-f]quinolines:Synthesis, Cytotoxicity and Drug Delivery Studies

Andrew Tsotinis; Marilena Vlachou; Maria Gerasimopoulou; Aphrodite Eikosipentaki; Constantine Ioannidis; Anna Klouvidaki; Pandelis A. Afroudakis; Dimitri Moreau; Christos Roussakis

doi:10.2174/157018007779422488

ISSN: 1570-1808
E-ISSN: 1875-628X

Symmetrical Derivatives of C2-Substituted Pyrrolo[2,3-f]quinolines:Synthesis, Cytotoxicity and Drug Delivery Studies
Authors: Andrew Tsotinis¹, Marilena Vlachou², Maria Gerasimopoulou³, Aphrodite Eikosipentaki⁴, Constantine Ioannidis⁵, Anna Klouvidaki⁶, Pandelis A. Afroudakis⁷, Dimitri Moreau⁸ and Christos Roussakis⁹
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¹ Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Athens,Panepistimioupoli-Zografou, 157 71 Athens, Greece. ² Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Athens,Panepistimioupoli-Zografou, 157 71 Athens, Greece. ³ Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Athens,Panepistimioupoli-Zografou, 157 71 Athens, Greece. ⁴ Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Athens,Panepistimioupoli-Zografou, 157 71 Athens, Greece. ⁵ Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Athens,Panepistimioupoli-Zografou, 157 71 Athens, Greece. ⁶ Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Athens,Panepistimioupoli-Zografou, 157 71 Athens, Greece. ⁷ Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Athens,Panepistimioupoli-Zografou, 157 71 Athens, Greece. ⁸ Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Athens,Panepistimioupoli-Zografou, 157 71 Athens, Greece. ⁹ Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Athens,Panepistimioupoli-Zografou, 157 71 Athens, Greece.
Source: Letters in Drug Design & Discovery, Volume 4, Issue 2, Mar 2007, p. 87 - 91
DOI: https://doi.org/10.2174/157018007779422488
- Available online: 01 Mar 2007

Abstract

The synthesis, pharmacological properties and delivery characteristics in simulated aqueous gastric fluid of a series of symmetrical nitrogenated C2-substituted pyrrolo[2,3-f]quinolines are described. The cytotoxicity of the target molecules (5a-h) was evaluated in the human non-small lung cancer cell line NSCLCN16- L16 in vitro. One compound (5e) showed sufficient activity (IC50 = 26.4 μM) and satisfactory release characteristics from solid pharmaceutical formulations.

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2007-03-01

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Article Type: Research Article

Keyword(s): Cytotoxicity; Drug delivery; Symmetrical pyrrolo[2,3-f]quinolines; Synthesis

Symmetrical Derivatives of C2-Substituted Pyrrolo[2,3-f]quinolines:Synthesis, Cytotoxicity and Drug Delivery Studies

Abstract

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