Inhibitors of the Chemokine Receptor CXCR4: Chemotherapy of AIDS, Metastatic Cancer, Leukemia and Rheumatoid Arthritis

Hiroshi Tsutsumi; Hirokazu Tamamura; Nobutaka Fujii

doi:10.2174/157018007778992900

ISSN: 1570-1808
E-ISSN: 1875-628X

Inhibitors of the Chemokine Receptor CXCR4: Chemotherapy of AIDS, Metastatic Cancer, Leukemia and Rheumatoid Arthritis
Authors: Hiroshi Tsutsumi¹, Hirokazu Tamamura² and Nobutaka Fujii³
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¹ Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda-ku,Tokyo 101-0062, Japan. ² Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda-ku,Tokyo 101-0062, Japan. ³ Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda-ku,Tokyo 101-0062, Japan.
Source: Letters in Drug Design & Discovery, Volume 4, Issue 1, Jan 2007, p. 20 - 26
DOI: https://doi.org/10.2174/157018007778992900
- Available online: 01 Jan 2007

Abstract

The interaction between the chemokine, CXCL12 and its receptor, CXCR4 is known to be involved in several intractable disease processes, including HIV infection, cancer cell metastasis, leukemia cell progression and rheumatoid arthritis. It is conjectured that this interaction may be an important therapeutic target in all of these diseases, and various CXCR4 antagonists have been proposed as potential drugs. This article describes the development in our laboratory of a number of specific CXCR4 antagonists.

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2007-01-01

2025-05-29

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Article Type: Research Article

Keyword(s): Cancer metastasis; Chemokine receptor; HIV infection; Leukemia cell progression; Low molecular weight CXCR4 antagonist; Rheumatoid arthritis

Inhibitors of the Chemokine Receptor CXCR4: Chemotherapy of AIDS, Metastatic Cancer, Leukemia and Rheumatoid Arthritis

Abstract

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