Design, Synthesis and Evaluation of Peroxisome Proliferator-Activated Receptor α/βDual Agonists for the Treatment of Type 2 Diabetes

Saibal Kumar Das; Chandrasekhar Abbineni; Krovvidi Venkata Lakshmi Narasimha Rao; Javed Iqbal; Ravi Krishna Babu; Ranjan Chakrabarti

doi:10.2174/157018007778992883

ISSN: 1570-1808
E-ISSN: 1875-628X

Design, Synthesis and Evaluation of Peroxisome Proliferator-Activated Receptor α/βDual Agonists for the Treatment of Type 2 Diabetes
Authors: Saibal Kumar Das¹, Chandrasekhar Abbineni², Krovvidi Venkata Lakshmi Narasimha Rao³, Javed Iqbal⁴, Ravi Krishna Babu⁵ and Ranjan Chakrabarti⁶
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¹ Metabolic Disorders Group,Discovery Research, Dr. Reddy's Laboratories Ltd, Bollaram Road,Miyapur, Hyderabad 500 049, AP, India. ² Metabolic Disorders Group,Discovery Research, Dr. Reddy's Laboratories Ltd, Bollaram Road,Miyapur, Hyderabad 500 049, AP, India. ³ Metabolic Disorders Group,Discovery Research, Dr. Reddy's Laboratories Ltd, Bollaram Road,Miyapur, Hyderabad 500 049, AP, India. ⁴ Metabolic Disorders Group,Discovery Research, Dr. Reddy's Laboratories Ltd, Bollaram Road,Miyapur, Hyderabad 500 049, AP, India. ⁵ Metabolic Disorders Group,Discovery Research, Dr. Reddy's Laboratories Ltd, Bollaram Road,Miyapur, Hyderabad 500 049, AP, India. ⁶ Metabolic Disorders Group,Discovery Research, Dr. Reddy's Laboratories Ltd, Bollaram Road,Miyapur, Hyderabad 500 049, AP, India.
Source: Letters in Drug Design & Discovery, Volume 4, Issue 1, Jan 2007, p. 27 - 32
DOI: https://doi.org/10.2174/157018007778992883
- Available online: 01 Jan 2007

Abstract

The design, synthesis and evaluation of several dual PPARα/γ agonists with three different heterocycles, viz. pyrazolo[4,3-d]pyrimidin-7-one, quinazolin-4-one and benzo[e][1,3]oxazine-4-one for the treatment of type 2 diabetes and associated dyslipidemia are described. Among them, compound 5cb was found to possess a potent dual PPARα/β agonist property. It significantly reversed diabetic hyperglycemia while improving overall lipid homeostasis in preclinical animal models.

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2007-01-01

2025-05-27

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Article Type: Research Article

Keyword(s): Diabetes; Dyslipidemia and Plasma glucose; Ethyl 3-(4-aminophenyl)-2-ethoxypropionate; PPAR; Synthesis

Design, Synthesis and Evaluation of Peroxisome Proliferator-Activated Receptor α/βDual Agonists for the Treatment of Type 2 Diabetes

Abstract

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