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2000
Volume 2, Issue 7
  • ISSN: 1570-1808
  • E-ISSN: 1875-628X

Abstract

A series of eight N'-[(E)-(disubstituted-phenyl)methylidene]isonicotino-hydrazide derivatives were synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis, and the activity expressed as the minimum inhibitory concentration (MIC) in mg/mL. Four compounds 2b-d and 2f exhibited a significant activity (0.6 mg/mL), when compared with first line drugs such as isoniazid (INH) and rifampin (RIP) and could be a good starting point to develop new lead compounds in the fight against multidrug resistant tuberculosis.

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/content/journals/lddd/10.2174/157018005774479131
2005-11-01
2025-06-11
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/content/journals/lddd/10.2174/157018005774479131
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  • Article Type:
    Research Article
Keyword(s): antimycobacterial activity; Isoniazid; tuberculosis
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