L-Dopa Related Hyperhomocysteinemia: A Possible Mediator of Toxicity?

Stefano Zoccolella; Giovanni Iliceto; Michele deMari; Giovanni Defazio; Paolo Livrea; Paolo Lamberti

doi:10.2174/157018005774479113

ISSN: 1570-1808
E-ISSN: 1875-628X

L-Dopa Related Hyperhomocysteinemia: A Possible Mediator of Toxicity?
Authors: Stefano Zoccolella¹, Giovanni Iliceto², Michele deMari³, Giovanni Defazio⁴, Paolo Livrea⁵ and Paolo Lamberti⁶
View Affiliations Hide Affiliations

¹ Department of Neurological Sciences, University of Bari, Ospedale Policlinico, P.zza G. Cesare 11, 70124 Bari, Italy ² Department of Neurological Sciences, University of Bari, Ospedale Policlinico, P.zza G. Cesare 11, 70124 Bari, Italy ³ Department of Neurological Sciences, University of Bari, Ospedale Policlinico, P.zza G. Cesare 11, 70124 Bari, Italy ⁴ Department of Neurological Sciences, University of Bari, Ospedale Policlinico, P.zza G. Cesare 11, 70124 Bari, Italy ⁵ Department of Neurological Sciences, University of Bari, Ospedale Policlinico, P.zza G. Cesare 11, 70124 Bari, Italy ⁶ Department of Neurological Sciences, University of Bari, Ospedale Policlinico, P.zza G. Cesare 11, 70124 Bari, Italy
Source: Letters in Drug Design & Discovery, Volume 2, Issue 7, Nov 2005, p. 558 - 562
DOI: https://doi.org/10.2174/157018005774479113
- Available online: 01 Nov 2005

Abstract

L-dopa is the most effective drug in the symptomatic management of PD and extends the life span of PD patients.The question whether L-dopa is neurotoxic remains however unresolved. In recent years, increased Homocysteine (Hcy) levels have been observed in L-dopa treated Parkinson's disease (PD) patients, resulting from L-dopa O-methylation by the enzyme catechol-O-methyltransferase. This review summarizes current evidences supporting the possible role of Hcy as mediator of L-dopa toxicity mainly on dopaminergic neurons.

Article metrics loading...

/content/journals/lddd/10.2174/157018005774479113

2005-11-01

2025-05-25

From This Site

/content/journals/lddd/10.2174/157018005774479113

dcterms_title,dcterms_subject,pub_keyword

-contentType:Contributor -contentType:Concept -contentType:Institution

10

5

Full text loading...

/content/journals/lddd/10.2174/157018005774479113

Article Type: Research Article

Keyword(s): dopaminergic neurons; Homocysteine; Levodopa; Parkinson's disease; toxicity

L-Dopa Related Hyperhomocysteinemia: A Possible Mediator of Toxicity?

Abstract

From This Site

Most Read This Month

Most Cited Most Cited RSS feed

Discovery, Structural Determination and Anticancer Activities of Lactucinlike Guaianolides

Thermodynamic Aspects of Cancer: Possible Role of Negative Entropy in Tumor Growth, its Relation to Kinetic and Genetic Resistance

Immunomodulatory Properties of Synthetic Imidazolone Derivatives

Design and Prediction of ADME/Tox Properties of Novel Magnolol Derivatives as Anticancer Agents for NSCLC Using 3D-QSAR, Molecular Docking, MOLCAD and MM-GBSA Studies

Redox Active Iron at the Center of Oxidative Stress in Alzheimer Disease

Identifying Protein Binding Sites and Optimal Ligands

Phenyldihydroxypyrimidines as HCV NS5B RNA Dependent RNA Polymerase Inhibitors. Part I: Amides and Ureas

Phenyldihydroxypyrimidines as HCV NS5B RNA Dependent RNA Polymerase Inhibitors. Part II: Sulfonamides

Selection of a Catalytically Active Enzyme In Vivo Via Phage Display of its Product

A Comprehensive Review of the Advancement in Omic Technologies in the Field of Drug Discovery and Development