Solution-Phase Parallel Synthesis of N,6-Disubstituted Isoquinuclidines as Ibogaine Analogs

M. S. Levi; M. O.F. Khan; R. F. Borne

doi:10.2174/1570180053398217

ISSN: 1570-1808
E-ISSN: 1875-628X

Solution-Phase Parallel Synthesis of N,6-Disubstituted Isoquinuclidines as Ibogaine Analogs
Authors: M. S. Levi¹, M. O.F. Khan² and R. F. Borne³
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¹ Department of Medicinal Chemistry and Laboratory for Applied Drug Design and Synthesis, School of Pharmacy, University of Mississippi, University, MS 38677, USA. ² Department of Medicinal Chemistry and Laboratory for Applied Drug Design and Synthesis, School of Pharmacy, University of Mississippi, University, MS 38677, USA. ³ Department of Medicinal Chemistry and Laboratory for Applied Drug Design and Synthesis, School of Pharmacy, University of Mississippi, University, MS 38677, USA.
Source: Letters in Drug Design & Discovery, Volume 2, Issue 1, Feb 2005, p. 51 - 54
DOI: https://doi.org/10.2174/1570180053398217
- Available online: 01 Feb 2005

Abstract

The naturally-occurring alkaloid ibogaine, found in the West African shrub Tabernanthe iboga, possesses the ability to diminish self-administration of substances of abuse, such as cocaine, heroin and alcohol. This was the lead structure for the design of a 75-member library of N,6-disubstituted isoquinuclidines. A solution-phase method for their synthesis is described.

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2005-02-01

2025-05-30

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Article Type: Review Article

Keyword(s): addiction; anti-addictive; ibogaine; isoquinuclidine; parallel synthesis

Solution-Phase Parallel Synthesis of N,6-Disubstituted Isoquinuclidines as Ibogaine Analogs

Abstract

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