Inhibition of Human Melanoma Cell Replication Using Protein Transduction Technology with a Uracil-DNA Glycosylase Inhibitor

We demonstrated that the uracil-DNA glycosylase inhibitor, when delivered to human melanoma cells using protein transduction technology, resulted in a dose and time dependent inhibition of uracil-DNA glycosylase (UNG) and this inhibited cell proliferation. These results suggest that a novel class of inhibitors specifically targeting UNG can be developed as potential anti-cancer agents.