Mitotic Checkpoint: A Therapeutic Target in the Treatment of Human Cancer

Xianghong Wang; Y. C. Wong; Dong-Yan Jin

doi:10.2174/1570180053175098

ISSN: 1570-1808
E-ISSN: 1875-628X

Mitotic Checkpoint: A Therapeutic Target in the Treatment of Human Cancer
Authors: Xianghong Wang¹, Y. C. Wong² and Dong-Yan Jin³
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¹ Dept. of Anatomy, Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, 1/F, Lab. Complex, Hong Kong, SAR, China. ² Dept. of Anatomy, Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, 1/F, Lab. Complex, Hong Kong, SAR, China. ³ Dept. of Anatomy, Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, 1/F, Lab. Complex, Hong Kong, SAR, China.
Source: Letters in Drug Design & Discovery, Volume 2, Issue 2, Mar 2005, p. 97 - 104
DOI: https://doi.org/10.2174/1570180053175098
- Available online: 01 Mar 2005

Abstract

The most common feature of human cancer cells is aneuploidy and a defective mitotic checkpoint is thought to be responsible. Since a group of anticancer drugs target the mitotic checkpoint, this review will discuss the association of mitotic checkpoint with chemotherapeutic drug sensitivity and suggest a novel therapeutic tool to achieve chemosensitization in human cancer cells.

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2005-03-01

2025-05-21

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Article Type: Review Article

Keyword(s): cell cycle checkpoints; chromosome; dna replication; eukaryotic cells; kinetochores

Mitotic Checkpoint: A Therapeutic Target in the Treatment of Human Cancer

Abstract

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