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Volume 21, Issue 17
  • ISSN: 1570-1808
  • E-ISSN: 1875-628X

Abstract

Objective

Approximately 10%-40% of the global population is affected by allergic rhinitis, and has a long history of dual use as a herbal medicine and also as a food. This study utilized network pharmacology and molecular docking to explore the mechanism of action of in treating allergic rhinitis.

Methods

We screened active ingredients and potential action targets of using the TCMSP database. Relevant targets for allergic rhinitis diseases were accessed through the GeneCards and OMIM databases. GO function enrichment and KEGG pathway enrichment analyses of key targets were conducted using the DAVID database. Molecular docking validation was performed using Autodock Vina software to confirm the affinity between the core protein targets and the key active ingredients.

Results

Network pharmacological analysis identified 35 major active ingredients of , 87 drug targets, and 2200 disease targets. GO functional analysis and KEGG pathway enrichment analysis revealed that the mechanism of action of in treating allergic rhinitis involves multiple pathways, including the HIF-1 signaling pathway, IL-17 signaling pathway, and TNF signaling pathway. Molecular docking results demonstrated good binding activity between the main active ingredients and the core protein target.

Conclusion

exhibits multi-component, multi-target, and multi-pathway actions in treating allergic rhinitis by regulating relevant pathways and targets.

© 2024 Bentham Science Publishers
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2025-06-26

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/content/journals/lddd/10.2174/0115701808316186240913081055
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Exploring the Mechanism of Action of Lycium barbarum in Treating Allergic Rhinitis Using Network Pharmacology and Molecular Docking
Letters in Drug Design & Discovery 21, 4095 (2024); https://doi.org/10.2174/0115701808316186240913081055
/content/journals/lddd/10.2174/0115701808316186240913081055
/content/journals/lddd/10.2174/0115701808316186240913081055
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  • Article Type:     Research Article
Keyword(s): active ingredients; allergic rhinitis; Lycium barbarum; mechanism of action; molecular docking; network pharmacology

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