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Volume 21, Issue 17
  • ISSN: 1570-1808
  • E-ISSN: 1875-628X
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Abstract

Background

Rheumatoid arthritis (RA) is a self-inflammatory disease with increasing global morbidity and high disability. The Chinese herbal medicine G. Dons has been conventionally used to control RA without side effects for hundreds of years, but its effect and mechanism for anti-RA are still unclear.

Objective

The objective of this study is to study the potential effect and mechanism of against RA from the perspective of action targets and molecular pathways.

Methods

In this study, systemic network pharmacology was used to explore the potential effect and mechanisms of against RA, including drug active components collection, target prediction, PPI network construction, and GO and KEGG pathway enrichment analyses. At last, molecular docking was carried out to estimate the pharmacological effects and mechanisms.

Results

A total of 19 drug-active compounds from and 188 potential therapeutic targets for RA were screened. According to the results of molecular docking, the interaction between 4 key active compounds (rhodojaponin III, quercetin, kaempferol, rhodojaponin VI) and 10 core target proteins (TNF, AKT1, ALB, IL-1β, TP53, EGFR, CASP3, MMP9, PTGS2, BCL2) is the closest. The results of enrichment analysis showed that the most enriched pathways were pathways related to inflammation, human T-cell leukemia virus type I infection, PI3K-Akt and IL-17.

Conclusion

The Chinese herbal medicine may regulate multiple pathways by interacting with multiple drug-active compounds and core targets, and cause the patient's immune system to respond accordingly, reducing the release of inflammatory factors, and relieving joint pain.

© 2024 Bentham Science Publishers
© 2024 The Author(s). Published by Bentham Science Publisher. This is an open access article published under CC BY 4.0 https://creativecommons.org/licenses/by/4.0/legalcode
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2024-06-05
2025-05-11

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The Potential Effects and Mechanisms of Rhododendron molle against Rheumatoid Arthritis Based on Network Pharmacology and Molecular Docking
Letters in Drug Design & Discovery 21, 3790 (2024); https://doi.org/10.2174/0115701808300289240530114612
/content/journals/lddd/10.2174/0115701808300289240530114612
/content/journals/lddd/10.2174/0115701808300289240530114612
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  • Article Type:     Research Article
Keyword(s): action target; drug active compound; molecular docking; network pharmacology; rheumatoid arthritis; Rhododendron molle

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