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Volume 21, Issue 17
  • ISSN: 1570-1808
  • E-ISSN: 1875-628X

Abstract

Background

Intra-abdominal adhesions are a commonly occurring postoperative complication following abdominopelvic surgery. Peritoneal adhesion formation can lead to infertility, chronic pelvic pain, and intestinal obstruction. The anti-inflammatory and anti-oxidant activities of () and Mill () have been reported. Here, we have explored the therapeutic potential of () and against postsurgical adhesion band formation. The NC3Rs ARRIVE guidelines were followed during experimental studies.

Methods

powder (800 mg/kg) and powder (400 mg/kg) were administered using oral gavage to different groups of male albino Wistar rats. After ten days of treatment, macroscopic evidence for peritoneal adhesions and adhesion band score were determined. Furthermore, the anti-inflammatory and antifibrosis effects of and were assessed using histopathology, ELISA, and real-time polymerase chain reaction methods. Also, alterations in some oxidative stress parameters were evaluated.

Results

and significantly decreased adhesion bands and were associated with a reduction in inflammatory cell infiltration into damaged tissues and the mRNA and protein expression of inflammatory cytokines modulation of TNF-α, IL-6, IL-1β, and TGF-β. Moreover, both agents inhibited fibrotic adhesion band formation by decreasing collagen deposition and reducing profibrotic marker expression, Col1A1, at the peritoneum adhesion tissues. and improved some antioxidant factors in rats’ adhesion tissues. The result of LC-MS showed that and consist of components with antioxidant activity, including ganoderic acid, lucidenic acid, quercetin, linoleic acid, malic acid, and benzoic acid.

Conclusion

The results have demonstrated the therapeutic potential of and in reducing peritoneal adhesion through anti-inflammatory and anti-fibrotic properties, indicating their promising value as a new therapeutic approach in preventing postsurgical adhesion.

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2025-06-24

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/content/journals/lddd/10.2174/0115701808298079240818170758
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The Therapeutic Potential of Ganoderma lucidum Karst and Ziziphus jujuba Mill for Postsurgical Adhesion Band Formation
Letters in Drug Design & Discovery 21, 3955 (2024); https://doi.org/10.2174/0115701808298079240818170758
/content/journals/lddd/10.2174/0115701808298079240818170758
/content/journals/lddd/10.2174/0115701808298079240818170758
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  • Article Type:     Research Article
Keyword(s): ELISA; fibrosis; Ganoderma lucidum Karst; postsurgical adhesion band formation; SBO; Ziziphus jujuba mill

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